| Gene Symbol |
ADCY1
|
| Entrez Gene |
107
|
| Alt Symbol |
AC1, DFNB44
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenylate cyclase 1 (brain)
|
| Other Description |
3',5'-cyclic AMP synthetase|ATP pyrophosphate-lyase 1|Ca(2+)/calmodulin-activated adenylyl cyclase|adenyl cyclase|adenylate cyclase type 1|adenylate cyclase type I|adenylyl cyclase 1
|
| Swissprots |
Q08828 Q75MI1 A4D2L8
|
| Accessions |
AAS07467 CAD99233 EAL23741 EAW61042 EAW61043 EAW61044 EAW61045 EAW61046 EAW61047 Q08828 AB209496 BAD92733 AF086306 AF497515 AAM94372 AK024415 AK055343 AK095518 AK095665 AL707720 AW956248 BC036858 BC041473 BC169213 BC169214 BU181704 L05500 AAA02907 XM_005249584 XP_005249641 XM_005249585 XP_005249642 NM_001281768 NP_001268697 NM_021116 NP_066939
|
| Function |
This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O88444}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}.
|
| Tissue Specificity |
Brain, retina and adrenal medulla.
|
| Top Pathways |
Oxytocin signaling pathway, Adrenergic signaling in cardiomyocytes, Inflammatory mediator regulation of TRP channels, Calcium signaling pathway, Gap junction
|
![Western Blot: Adenylate Cyclase 1 Overexpression Lysate (Adult Normal) [NBP2-06564] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Adenylate Cyclase 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10304_Adenylate%2520Cyclase%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06564-img0001.jpg)