ADCY1
| Gene Symbol | ADCY1 |
|---|---|
| Entrez Gene | 107 |
| Alt Symbol | AC1, DFNB44 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adenylate cyclase 1 (brain) |
| Other Description | 3',5'-cyclic AMP synthetase|ATP pyrophosphate-lyase 1|Ca(2+)/calmodulin-activated adenylyl cyclase|adenyl cyclase|adenylate cyclase type 1|adenylate cyclase type I|adenylyl cyclase 1 |
| Swissprots | Q08828 Q75MI1 A4D2L8 |
| Accessions | AAS07467 CAD99233 EAL23741 EAW61042 EAW61043 EAW61044 EAW61045 EAW61046 EAW61047 Q08828 AB209496 BAD92733 AF086306 AF497515 AAM94372 AK024415 AK055343 AK095518 AK095665 AL707720 AW956248 BC036858 BC041473 BC169213 BC169214 BU181704 L05500 AAA02907 XM_005249584 XP_005249641 XM_005249585 XP_005249642 NM_001281768 NP_001268697 NM_021116 NP_066939 |
| Function | This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O88444}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}. |
| Tissue Specificity | Brain, retina and adrenal medulla. |
| Top Pathways | Oxytocin signaling pathway, Adrenergic signaling in cardiomyocytes, Inflammatory mediator regulation of TRP channels, Calcium signaling pathway, Gap junction |
A cyclase I CRISPR/Cas9 KO Plasmid (h) - sc-402115 from Santa Cruz Biotechnology
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A cyclase I HDR Plasmid (h) - sc-402115-HDR from Santa Cruz Biotechnology
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A cyclase I Double Nickase Plasmid (h) - sc-402115-NIC from Santa Cruz Biotechnology
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A cyclase I Double Nickase Plasmid (h2) - sc-402115-NIC-2 from Santa Cruz Biotechnology
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A cyclase I CRISPR Activation Plasmid (h) - sc-402115-ACT from Santa Cruz Biotechnology
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A cyclase I CRISPR Activation Plasmid (h2) - sc-402115-ACT-2 from Santa Cruz Biotechnology
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A cyclase I Lentiviral Activation Particles (h) - sc-402115-LAC from Santa Cruz Biotechnology
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A cyclase I Lentiviral Activation Particles (h2) - sc-402115-LAC-2 from Santa Cruz Biotechnology
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A cyclase I siRNA (h) - sc-40316 from Santa Cruz Biotechnology
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A cyclase I shRNA Plasmid (h) - sc-40316-SH from Santa Cruz Biotechnology
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A cyclase I shRNA (h) Lentiviral Particles - sc-40316-V from Santa Cruz Biotechnology
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Adenylate Cyclase 1 RNAi - H00000107-R01 from Novus Biologicals
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MISSION® esiRNA - EHU042741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2859 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2859 from Sigma-Aldrich
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ADCY1 siRNA (Human) - CRH0070 from Cohesion Biosciences
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ADCY1 - MBS8219200 from MyBioSource
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shRNA set against Human ADCY1 (NM_021116.2) - SHH232158 from Creative biogene
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shRNA set against Human ADCY1(NM_021116.2) - SHG041077 from Creative biogene
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ADCY1 shRNA Plasmid (Human) - CHH0070 from Cohesion Biosciences
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ADCY1 miRNA 3'UTR clone - MiUTR1H-00184 from Creative biogene
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