OPRL1

Gene Symbol	OPRL1
Entrez Gene	4987
Alt Symbol	KOR-3, NOCIR, OOR, ORL1
Species	Human
Gene Type	protein-coding
Description	opiate receptor-like 1
Other Description	kappa-type 3 opioid receptor|kappa3-related opioid receptor|nociceptin receptor|orphanin FQ receptor
Swissprots	Q8TD34 P41146 Q8WYH9 Q9H4K4
Accessions	AAG42351 EAW75162 EAW75163 P41146 AF115266 AAO13224 AF126470 AAL54890 AF285093 AAG42691 AF285094 AAG42692 AF285095 AAG42693 AF348323 AAK11714 AK308203 AW451157 AY268428 AAP23195 BC038433 AAH38433 CN267465 CR542061 CAG46858 CR542082 CAG46879 DQ893206 ABM84132 DQ893207 ABM84133 EU176792 ABW03593 L40949 AAA96251 U30185 AAA84913 X77130 CAA54386 XM_011528828 XP_011527130 XM_011528829 XP_011527131 XM_011528830 XP_011527132 NM_000913 NP_000904 NM_001200019 NP_001186948 NM_182647 NP_872588
Function	G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.
Tissue Specificity	Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nociceptin receptor (OPRL1), Human, ELISA Kit - E01N0566 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Nociceptin receptor, OPRL1, Human, ELISA Kit - E9791h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

Nociceptin Receptor (NOCIR), ELISA Kit - MBS9311050 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7248924 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7237426 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7226931 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7205689 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7235663 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7215967 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7229317 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7233201 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7220687 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7230420 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nociceptin receptor (OPRL1), ELISA Kit - MBS7218428 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pig OPRL1 / ORL1 ELISA Kit (Custom ELISA) - LS-F20562 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Rat OPRL1 / ORL1 ELISA Kit (Custom ELISA) - LS-F20564 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Human OPRL1 / ORL1 ELISA Kit (Custom ELISA) - LS-F20563 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Mouse OPRL1 / ORL1 ELISA Kit (Custom ELISA) - LS-F20561 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Human Nociceptin receptor ELISA Kit - abx251883 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human Nociceptin receptor ELISA Kit - EKE54719 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 27 pg/mL Range 78-5000 pg/mL

OPRL1 - EKH5024 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

Human OPRL1 ELISA Kit - E026684 from Biobool Category ELISA Kit Sensitivity <46.9pg/ml

Human NOCIR ELISA Kit - E026686 from Biobool Category ELISA Kit

OPRL1 ELISA Kit (Human) (OKEH04958) - OKEH04958 from Aviva Systems Biology Category ELISA Kit Prices $500.00 Sizes 96 wells Sensitivity 39 pg/mL Range 78-5,000 pg/mL

OPRL1 ELISA Kit (Human) (OKEH06824) - OKEH06824 from Aviva Systems Biology Category ELISA Kit Prices $510.00 Sizes 96 wells Sensitivity 27pg/mL Range 78-5,000 pg/mL

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