| Gene Symbol | OPRL1 |
|---|---|
| Entrez Gene | 4987 |
| Alt Symbol | KOR-3, NOCIR, OOR, ORL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | opiate receptor-like 1 |
| Other Description | kappa-type 3 opioid receptor|kappa3-related opioid receptor|nociceptin receptor|orphanin FQ receptor |
| Swissprots | Q8TD34 P41146 Q8WYH9 Q9H4K4 |
| Accessions | AAG42351 EAW75162 EAW75163 P41146 AF115266 AAO13224 AF126470 AAL54890 AF285093 AAG42691 AF285094 AAG42692 AF285095 AAG42693 AF348323 AAK11714 AK308203 AW451157 AY268428 AAP23195 BC038433 AAH38433 CN267465 CR542061 CAG46858 CR542082 CAG46879 DQ893206 ABM84132 DQ893207 ABM84133 EU176792 ABW03593 L40949 AAA96251 U30185 AAA84913 X77130 CAA54386 XM_011528828 XP_011527130 XM_011528829 XP_011527131 XM_011528830 XP_011527132 NM_000913 NP_000904 NM_001200019 NP_001186948 NM_182647 NP_872588 |
| Function | G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane. |
| Tissue Specificity | Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}. |
| Top Pathways | Neuroactive ligand-receptor interaction |