OPRL1

Gene Symbol	OPRL1
Entrez Gene	4987
Alt Symbol	KOR-3, NOCIR, OOR, ORL1
Species	Human
Gene Type	protein-coding
Description	opiate receptor-like 1
Other Description	kappa-type 3 opioid receptor|kappa3-related opioid receptor|nociceptin receptor|orphanin FQ receptor
Swissprots	Q8TD34 P41146 Q8WYH9 Q9H4K4
Accessions	AAG42351 EAW75162 EAW75163 P41146 AF115266 AAO13224 AF126470 AAL54890 AF285093 AAG42691 AF285094 AAG42692 AF285095 AAG42693 AF348323 AAK11714 AK308203 AW451157 AY268428 AAP23195 BC038433 AAH38433 CN267465 CR542061 CAG46858 CR542082 CAG46879 DQ893206 ABM84132 DQ893207 ABM84133 EU176792 ABW03593 L40949 AAA96251 U30185 AAA84913 X77130 CAA54386 XM_011528828 XP_011527130 XM_011528829 XP_011527131 XM_011528830 XP_011527132 NM_000913 NP_000904 NM_001200019 NP_001186948 NM_182647 NP_872588
Function	G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.
Tissue Specificity	Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nociceptin receptor full length protein - ab132713 from Abcam Category Protein Source Wheat germ Species Human

Human Nociceptin receptor protein fragment - ab159028 from Abcam Category Protein Source Wheat germ Species Human

Nociceptin receptor peptide - ab129205 from Abcam Category Peptide

OPRL1 / ORL1 Antibody Blocking Peptide - LS-E21797 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ORL1/OPRL1 Protein - H00004987-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ORL1/OPRL1 Recombinant Protein - H00004987-P01 from Novus Biologicals Category Protein Species Human

OPRL1 Blocking Peptide - 33R-4167 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Nociceptin receptor / OPRL1 - H00004987-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

Nociceptin receptor / OPRL1 - H00004987-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Nociceptin receptor / OPRL1 - H00004987-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ORL-1 Peptide - 214-10029 from RayBiotech Category Peptide

OPRL1 fusion protein - ag4079 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ORL1/OPRL1 Protein - H00004987-G01 from Novus Biologicals Category Protein Prices $415.00 Sizes 2 µg Source Wheat Germ Species Human

Nociceptin, Peptide - MBS658179 from MyBioSource Category Peptide Prices $330.00 Sizes 5 mg Source Synthetic peptide

Nociceptin, Peptide - MBS659755 from MyBioSource Category Peptide Prices $280.00 Sizes 5 mg Source Synthetic peptide

OPRL1 Peptide, Human - M34GP10863H from Creative Peptides Category Peptide Source Synthetic. Species Human

Nociceptin receptor (OPRL1), Recombinant Protein - MBS954000 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Nociceptin receptor (OPRL1), Recombinant Protein - MBS7024630 from MyBioSource Category Protein Prices $1,180.00, $2,165.00, $3,370.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Nociceptin receptor peptide - orb73030 from Biorbyt Category Peptide

ORL-1 peptide - orb319743 from Biorbyt Category Peptide

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