DVL1

Gene Symbol DVL1
Entrez Gene 1855
Alt Symbol DVL, DVL1L1, DVL1P1
Species Human
Gene Type protein-coding
Description dishevelled segment polarity protein 1
Other Description DSH homolog 1|dishevelled 1 (homologous to Drosophila dsh)|dishevelled, dsh homolog 1|dishevelled-1|segment polarity protein dishevelled homolog DVL-1
Swissprots O14640 Q5TA35 Q5TA33
Accessions EAW56224 EAW56225 EAW56226 EAW56227 O14640 P54792 AB209210 BAD92447 AF006011 AAB65242 AK093189 BAC04089 AK095867 BAG53150 AK293286 BAH11484 AK300063 BAH13201 BC017225 AAH17225 BC025292 BC050454 AAH50454 BC111419 BP305846 U46461 AAC50682 XM_005244731 XP_005244788 XM_005244732 XP_005244789 XM_005244733 XP_005244790 NM_004421 NP_004412 NM_181870 NM_182779
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
Top Pathways Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection

Dvl (B-4) - sc-166303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dvl (B-4): sc-166303. Western blot analysis of Dvl expression in HeLa whole cell lysate.

Dvl (C-19) - sc-7397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dvl (C-19): sc-7397. Western blot analysis of Dvl expression in mouse brain extract.

Dvl (H-260) - sc-25534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dvl (H-260): sc-25534. Western blot analysis of Dvl-2 expression in non-transfected: sc-110760 (A) and human Dvl-2 transfected: sc-111055 (B) 293 whole cell lysates.

Dvl-1 (3F12) - sc-8025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dvl-1 (3F12): sc-8025. Western blot analysis of Dvl-1 expression in SK-N-SH (A) and KNRK (B) whole cell lysates.

Dvl-1 (Q-25) - sc-133525 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Dvl-1 (Q-25): sc-133525. Western blot analysis of Dvl-1 expression in K-562 whole cell lysate.

Anti-Dishevelled / Dvl1 antibody - ab106844 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Dishevelled / Dvl1 staining in human testis formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab106844, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Dishevelled / Dvl1 antibody - ab170694 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HepG2 cells labeling Dishevelled / Dvl1 with ab170694 at 1/10 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) and DAPI staining.

Anti-Dishevelled / Dvl1 antibody - ab174679 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Dishevelled / Dvl1 antibody (ab174679) at 1 µg/ml + NIH3T3 lysate at 35 µg

Anti-DVL1 / DVL / Dishevelled Antibody (aa20-32) IHC-plus™ - LS-B11264 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DVL1 / DVL / Dishevelled antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-DVL1 / DVL / Dishevelled Antibody (aa441-470, APC) - LS-C256358 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa441-470, AP) - LS-C256357 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa441-470, Biotin) - LS-C256359 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa412-461) - LS-C79988 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.

Anti-DVL1 / DVL / Dishevelled Antibody (aa441-470, FITC) - LS-C256360 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa441-470, Azide-free, HRP) - LS-C256361 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa441-470, PE) - LS-C256362 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa150-332, Biotin) - LS-C297484 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa70-120) - LS-C148681 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DVL-1 in Raji cell lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148681 at 6 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-DVL1 / DVL / Dishevelled Antibody (aa150-285, Biotin) - LS-C300733 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa402-414) - LS-C186485 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
DVL1 antibody (1 ug/ml) staining of NIH3T3 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-DVL1 / DVL / Dishevelled Antibody (aa150-285, FITC) - LS-C302254 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa150-332, FITC) - LS-C304874 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DVL1 / DVL / Dishevelled Antibody (aa150-285) - LS-C293694 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant DVL1 / DVL / Dishevelled.

Anti-DVL1 / DVL / Dishevelled Antibody (aa150-332) - LS-C293693 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant DVL1 / DVL / Dishevelled.

Anti-DVL1 / DVL / Dishevelled Antibody - LS-C310194 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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