| Gene Symbol | DVL1 |
|---|---|
| Entrez Gene | 1855 |
| Alt Symbol | DVL, DVL1L1, DVL1P1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dishevelled segment polarity protein 1 |
| Other Description | DSH homolog 1|dishevelled 1 (homologous to Drosophila dsh)|dishevelled, dsh homolog 1|dishevelled-1|segment polarity protein dishevelled homolog DVL-1 |
| Swissprots | O14640 Q5TA35 Q5TA33 |
| Accessions | EAW56224 EAW56225 EAW56226 EAW56227 O14640 P54792 AB209210 BAD92447 AF006011 AAB65242 AK093189 BAC04089 AK095867 BAG53150 AK293286 BAH11484 AK300063 BAH13201 BC017225 AAH17225 BC025292 BC050454 AAH50454 BC111419 BP305846 U46461 AAC50682 XM_005244731 XP_005244788 XM_005244732 XP_005244789 XM_005244733 XP_005244790 NM_004421 NP_004412 NM_181870 NM_182779 |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection |
Dvl-1 CRISPR/Cas9 KO Plasmid (h) - sc-400785 from Santa Cruz Biotechnology
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Dvl-1 HDR Plasmid (h) - sc-400785-HDR from Santa Cruz Biotechnology
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Dvl-1 Double Nickase Plasmid (h) - sc-400785-NIC from Santa Cruz Biotechnology
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Dvl-1 Double Nickase Plasmid (h2) - sc-400785-NIC-2 from Santa Cruz Biotechnology
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Dvl-1 CRISPR Activation Plasmid (h) - sc-400785-ACT from Santa Cruz Biotechnology
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Dvl-1 CRISPR Activation Plasmid (h2) - sc-400785-ACT-2 from Santa Cruz Biotechnology
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Dvl-1 Lentiviral Activation Particles (h) - sc-400785-LAC from Santa Cruz Biotechnology
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Dvl-1 Lentiviral Activation Particles (h2) - sc-400785-LAC-2 from Santa Cruz Biotechnology
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Dvl-1 siRNA (h) - sc-35228 from Santa Cruz Biotechnology
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Dvl-1 shRNA Plasmid (h) - sc-35228-SH from Santa Cruz Biotechnology
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Dvl-1 shRNA (h) Lentiviral Particles - sc-35228-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU060361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7576 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7576 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06962 from Sigma-Aldrich
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DVL1 siRNA (Human) - CRH1301 from Cohesion Biosciences
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Dishevelled-1 RNAi - H00001855-R02 from Novus Biologicals
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Dishevelled 1/3 - MBS826843 from MyBioSource
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DVL1 - MBS8232004 from MyBioSource
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Dvl-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400785-KO-2 from Santa Cruz Biotechnology
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Dvl-1 HDR Plasmid (h2) - sc-400785-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DVL1(NM_004421.2) - SHH019783 from Creative biogene
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Dishevelled 1/3 siRNA - orb219208 from Biorbyt
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Human DVL1 siRNA - orb261803 from Biorbyt
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DVL1 shRNA Plasmid (Human) - CHH1301 from Cohesion Biosciences
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