DVL1

Gene Symbol DVL1
Entrez Gene 1855
Alt Symbol DVL, DVL1L1, DVL1P1
Species Human
Gene Type protein-coding
Description dishevelled segment polarity protein 1
Other Description DSH homolog 1|dishevelled 1 (homologous to Drosophila dsh)|dishevelled, dsh homolog 1|dishevelled-1|segment polarity protein dishevelled homolog DVL-1
Swissprots O14640 Q5TA35 Q5TA33
Accessions EAW56224 EAW56225 EAW56226 EAW56227 O14640 P54792 AB209210 BAD92447 AF006011 AAB65242 AK093189 BAC04089 AK095867 BAG53150 AK293286 BAH11484 AK300063 BAH13201 BC017225 AAH17225 BC025292 BC050454 AAH50454 BC111419 BP305846 U46461 AAC50682 XM_005244731 XP_005244788 XM_005244732 XP_005244789 XM_005244733 XP_005244790 NM_004421 NP_004412 NM_181870 NM_182779
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
Top Pathways Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection

DVL1-Over-expression-Lysate - LY12513a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag DVL1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DVL1 gene

DVL1 293T Cell Transient Overexpression Lysate(Denatured) - H00001855-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

DVL1 overexpression lysate - LY401404 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

DVL1 293 Cell Lysate - 401279 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg
Species Drosophila

Dishevelled-1 Overexpression Lysate (Native) - NBL1-10061 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: Dishevelled/Dvl1 Overexpression Lysate (Adult Normal) [NBL1-10061] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dishevelled/Dvl1.

Dishevelled-1 Overexpression Lysate (Native) - NBL1-10062 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Dishevelled/Dvl1 Overexpression Lysate (Adult Normal) [NBL1-10062] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dishevelled/Dvl1.

DVL1 Over-expression Lysate Product - GWB-AA67B2 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

DVL1 Over-expression Lysate Product - GWB-280C4D from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human DVL1 Knockdown Stable Cell Line - CSC-DC004634 from Creative biogene

Category Cell Line
Species Human
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