| Gene Symbol |
Foxo3
|
| Entrez Gene |
56484
|
| Alt Symbol |
1110048B16Rik, 2010203A17Rik, C76856, FKHRL1, Fkhr2, Foxo3a
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
forkhead box O3
|
| Other Description |
forkhead box O3a|forkhead box protein O3|forkhead protein FKHR2
|
| Swissprots |
Q05CZ4 D3Z6Y6 Q9WVH4
|
| Accessions |
EDL04998 Q9WVH4 AF114259 AAD42107 AK004198 AK008417 AK041595 BAE20596 AK047413 BAC33049 AK047922 AK079567 AK139629 AK143198 AK159465 BAE35106 BC019532 AAH19532 BC050975 BC100372 BC166015 AAI66015 XM_006512806 XP_006512869 NM_019740 NP_062714
|
| Function |
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in white and brown adipose tissues (at protein level). {ECO:0000269|PubMed:22510882}.
|
| Top Pathways |
Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway
|