Gene Symbol | Foxo3 |
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Entrez Gene | 56484 |
Alt Symbol | 1110048B16Rik, 2010203A17Rik, C76856, FKHRL1, Fkhr2, Foxo3a |
Species | Mouse |
Gene Type | protein-coding |
Description | forkhead box O3 |
Other Description | forkhead box O3a|forkhead box protein O3|forkhead protein FKHR2 |
Swissprots | Q05CZ4 D3Z6Y6 Q9WVH4 |
Accessions | EDL04998 Q9WVH4 AF114259 AAD42107 AK004198 AK008417 AK041595 BAE20596 AK047413 BAC33049 AK047922 AK079567 AK139629 AK143198 AK159465 BAE35106 BC019532 AAH19532 BC050975 BC100372 BC166015 AAI66015 XM_006512806 XP_006512869 NM_019740 NP_062714 |
Function | Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors. {ECO:0000250}. |
Tissue Specificity | Expressed in white and brown adipose tissues (at protein level). {ECO:0000269|PubMed:22510882}. |
Top Pathways | Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway |
Recombinant Forkhead Box Protein O3 (FOXO3) - RPA762Mu01 from Cloud-clone
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Recombinant Forkhead Box Protein O3 (FOXO3) - RPA762Mu02 from Cloud-clone
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Recombinant Mouse Forkhead box protein O3(Foxo3) - CSB-YP895304MO CSB-EP895304MO CSB-BP895304MO CSB-MP895304MO from Cusabio
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FOXO3 Protein - abx163265 from Abbexa
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Recombinant Mouse FOXO3 Protein - FOXO3-6007M from Creative Biomart
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Forkhead box protein O3 (Foxo3), Recombinant Protein - MBS1403260 from MyBioSource
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