Foxo3

Gene Symbol	Foxo3
Entrez Gene	56484
Alt Symbol	1110048B16Rik, 2010203A17Rik, C76856, FKHRL1, Fkhr2, Foxo3a
Species	Mouse
Gene Type	protein-coding
Description	forkhead box O3
Other Description	forkhead box O3a|forkhead box protein O3|forkhead protein FKHR2
Swissprots	Q05CZ4 D3Z6Y6 Q9WVH4
Accessions	EDL04998 Q9WVH4 AF114259 AAD42107 AK004198 AK008417 AK041595 BAE20596 AK047413 BAC33049 AK047922 AK079567 AK139629 AK143198 AK159465 BAE35106 BC019532 AAH19532 BC050975 BC100372 BC166015 AAI66015 XM_006512806 XP_006512869 NM_019740 NP_062714
Function	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors. {ECO:0000250}.
Tissue Specificity	Expressed in white and brown adipose tissues (at protein level). {ECO:0000269|PubMed:22510882}.
Top Pathways	Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® FoxO3a siRNA II (Mouse Specific) - 8702 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® FoxO3a siRNA I (Mouse Specific) - 8620 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

FKHRL1 CRISPR/Cas9 KO Plasmid (m) - sc-425192 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 HDR Plasmid (m) - sc-425192-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 Double Nickase Plasmid (m) - sc-425192-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 Double Nickase Plasmid (m2) - sc-425192-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 CRISPR Activation Plasmid (m) - sc-425192-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 CRISPR Activation Plasmid (m2) - sc-425192-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 Lentiviral Activation Particles (m) - sc-425192-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 Lentiviral Activation Particles (m2) - sc-425192-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHRL1 siRNA (m) - sc-37888 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

FKHRL1 shRNA Plasmid (m)-SH - sc-37888-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

FKHRL1 shRNA (m) Lentiviral Particles - sc-37888-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU045231 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN31521 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31521 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FOXO3 siRNA (Mouse) - CRM5827 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

FOXO3 - MBS8205449 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse FOXO3 (NM_019740.2) - SHH296769 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Foxo3a(NM_019740.2) - SHH067007 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse FOXO3 siRNA - orb285303 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

FOXO3 shRNA Plasmid (Mouse) - CHM5827 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

FOXO3 miRNA 3'UTR clone - MiUTR1M-04784 from Creative biogene Species Reactivities Mouse

Search more