| Gene Symbol | GOSR1 |
|---|---|
| Entrez Gene | 9527 |
| Alt Symbol | GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 |
| Species | Human |
| Gene Type | protein-coding |
| Description | golgi SNAP receptor complex member 1 |
| Other Description | 28 kDa Golgi SNARE protein|28 kDa cis-Golgi SNARE p28|Golgi SNAP receptor complex member 1|Golgi SNARE 28 kDa|cis-golgi SNARE|golgi integral membrane protein 2 |
| Swissprots | O95249 J3KST5 O75392 |
| Accessions | AAK01856 EAW51229 EAW51230 EAW51231 O95249 AF047438 AAC39889 AF073926 AAD12945 AK000606 AK074298 AK128816 AK291381 BAF84070 AK298714 BAG60870 AL049346 BC012620 AAH12620 BC040072 BC040471 AAH40471 BE785872 BG654545 CB054624 XM_005258070 XP_005258127 XM_005258071 XP_005258128 XM_005258072 XP_005258129 NM_001007024 NP_001007025 NM_001007025 NP_001007026 NM_004871 NP_004862 |
| Function | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}. |
| Top Pathways | SNARE interactions in vesicular transport |
Human GOSR1 Gene cDNA Clone - orb143417 from Biorbyt
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Human-GOSR1-cDNA-Clone - DC03473 from Abgent, a WuXi AppTec company
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GOSR1 - MBS1269165 from MyBioSource
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Human GOSR1 cDNA clone(NM_001007025.1) - CDFH007790 from Creative Biomart
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Human GOSR1 cDNA clone(NM_001007024.1) - CDFH007791 from Creative Biomart
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Human GOSR1 cDNA clone(NM_004871.2) - CDFH007792 from Creative Biomart
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Human GOSR1 ORF Clone(NM_004871.2) - CDCR289048 from Creative Biomart
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Human GOSR1 ORF Clone(NM_004871.2) - CDCR289049 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007024.1) - CDCR339785 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007024.1) - CDCR339786 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007025.1) - CDCR339787 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007025.1) - CDCR339788 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007025.1) - CDCR339789 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007024.1) - CDCL165032 from Creative Biomart
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Human GOSR1 ORF Clone(NM_001007024.1) - CDCL165033 from Creative Biomart
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Human GOSR1 Gene cDNA clone plasmid - HG14165-G from Sino Biological
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Human GOSR1/GS28 (NP_001007026) VersaClone cDNA - RDC1448 from R&D Systems
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Human GOSR1 ORF Clone(NM_004871.2) - CDCR289048 from Creative biogene
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Mouse GOSR1 ORF clone (NM_001007024.1) - CDCL113439 from Creative biogene
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Human GOSR1 ORF Clone (BC012620) - CDCS406302 from Creative biogene
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Human GOSR1 ORF clone (BC012620) - CDCB159332 from Creative biogene
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Human GOSR1 cDNA Clone(NM_001007025.1) - CDFH007790 from Creative biogene
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Human GOSR1 cDNA Clone(NM_001007024.1) - CDFH007791 from Creative biogene
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Human GOSR1 cDNA Clone(NM_004871.2) - CDFH007792 from Creative biogene
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Mouse GOSR1 ORF clone (NM_001007025.1) - CDCL113441 from Creative biogene
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