GOSR1
| Gene Symbol | GOSR1 |
|---|---|
| Entrez Gene | 9527 |
| Alt Symbol | GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 |
| Species | Human |
| Gene Type | protein-coding |
| Description | golgi SNAP receptor complex member 1 |
| Other Description | 28 kDa Golgi SNARE protein|28 kDa cis-Golgi SNARE p28|Golgi SNAP receptor complex member 1|Golgi SNARE 28 kDa|cis-golgi SNARE|golgi integral membrane protein 2 |
| Swissprots | O95249 J3KST5 O75392 |
| Accessions | AAK01856 EAW51229 EAW51230 EAW51231 O95249 AF047438 AAC39889 AF073926 AAD12945 AK000606 AK074298 AK128816 AK291381 BAF84070 AK298714 BAG60870 AL049346 BC012620 AAH12620 BC040072 BC040471 AAH40471 BE785872 BG654545 CB054624 XM_005258070 XP_005258127 XM_005258071 XP_005258128 XM_005258072 XP_005258129 NM_001007024 NP_001007025 NM_001007025 NP_001007026 NM_004871 NP_004862 |
| Function | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}. |
| Top Pathways | SNARE interactions in vesicular transport |
GS28 CRISPR/Cas9 KO Plasmid (h) - sc-404357 from Santa Cruz Biotechnology
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GS28 HDR Plasmid (h) - sc-404357-HDR from Santa Cruz Biotechnology
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GS28 Double Nickase Plasmid (h) - sc-404357-NIC from Santa Cruz Biotechnology
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GS28 Double Nickase Plasmid (h2) - sc-404357-NIC-2 from Santa Cruz Biotechnology
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GS28 CRISPR Activation Plasmid (h) - sc-404357-ACT from Santa Cruz Biotechnology
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GS28 CRISPR Activation Plasmid (h2) - sc-404357-ACT-2 from Santa Cruz Biotechnology
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GS28 Lentiviral Activation Particles (h) - sc-404357-LAC from Santa Cruz Biotechnology
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GS28 Lentiviral Activation Particles (h2) - sc-404357-LAC-2 from Santa Cruz Biotechnology
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GS28 siRNA (h) - sc-41306 from Santa Cruz Biotechnology
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GS28 shRNA Plasmid (h) - sc-41306-SH from Santa Cruz Biotechnology
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GS28 shRNA (h) Lentiviral Particles - sc-41306-V from Santa Cruz Biotechnology
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GOSR1 RNAi - H00009527-R03 from Novus Biologicals
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MISSION® esiRNA - EHU128281 from Sigma-Aldrich
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MISSION® esiRNA - EHU028991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9489 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9489 from Sigma-Aldrich
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GOSR1 siRNA (Human) - CRH6332 from Cohesion Biosciences
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GOSR1 RNAi - H00009527-R01 from Novus Biologicals
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GOSR1 RNAi - H00009527-R02 from Novus Biologicals
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GOSR1 - MBS8219094 from MyBioSource
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shRNA set against Human GOSR1 (NM_004871.2) - SHH305458 from Creative biogene
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shRNA set against Human GOSR1(NM_001007025.1) - SHH094601 from Creative biogene
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shRNA set against Human GOSR1(NM_001007024.1) - SHH094623 from Creative biogene
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shRNA set against Human GOSR1(NM_001007025.1) - SHH094659 from Creative biogene
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shRNA set against Human GOSR1(NM_004871.2) - SHH094673 from Creative biogene
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