| Gene Symbol |
Nos1
|
| Entrez Gene |
18125
|
| Alt Symbol |
2310005C01Rik, NO, NOS-I, Nos-1, bNOS, nNOS
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nitric oxide synthase 1, neuronal
|
| Other Description |
N-NOS|NC-NOS|NOS type I|constitutive NOS|neuronal NOS|neuronal nitric oxide synthase|nitric oxide synthase, brain|peptidyl-cysteine S-nitrosylase NOS1
|
| Swissprots |
Q64208 Q3UR10 Q9Z0J4
|
| Accessions |
EDL19803 Q9Z0J4 AK009163 AK141904 BAE24878 BC066101 BC083183 BC167235 AAI67235 D14552 BAA03415 S81982 AAB36469 U50718 XM_006530187 XP_006530250 XM_006530188 XP_006530251 XM_006530189 XP_006530252 XM_006530190 XP_006530253 XM_006530191 XP_006530254 XM_006530192 XP_006530255 NM_008712 NP_032738
|
| Function |
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Isoform NNOS Mu may be an effector enzyme for the dystrophin complex. {ECO:0000269|PubMed:17293453}.
|
| Subcellular Location |
Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed in the nervous system: expressed in cerebrum, olfactory bulb, hippocampus, midbrain, cerebellum, pons, medulla oblongata, and spinal cord. Also found in skeletal muscle, where it is localized beneath the sarcolemma of fast twitch muscle fibers, and in spleen, heart, kidney, and liver. N-NOS-1 and N-NOS-2 are found in all parts of the nervous system. NNOS beta and gamma occur in a region-specific manner in the brain and NNOS beta expression is developmentally regulated. NNOS Mu is only found in mature skeletal and cardiac muscles.
|
| Top Pathways |
Circadian entrainment, Phagosome, Salivary secretion, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS)
|