Nos1

Gene Symbol	Nos1
Entrez Gene	18125
Alt Symbol	2310005C01Rik, NO, NOS-I, Nos-1, bNOS, nNOS
Species	Mouse
Gene Type	protein-coding
Description	nitric oxide synthase 1, neuronal
Other Description	N-NOS|NC-NOS|NOS type I|constitutive NOS|neuronal NOS|neuronal nitric oxide synthase|nitric oxide synthase, brain|peptidyl-cysteine S-nitrosylase NOS1
Swissprots	Q64208 Q3UR10 Q9Z0J4
Accessions	EDL19803 Q9Z0J4 AK009163 AK141904 BAE24878 BC066101 BC083183 BC167235 AAI67235 D14552 BAA03415 S81982 AAB36469 U50718 XM_006530187 XP_006530250 XM_006530188 XP_006530251 XM_006530189 XP_006530252 XM_006530190 XP_006530253 XM_006530191 XP_006530254 XM_006530192 XP_006530255 NM_008712 NP_032738
Function	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Isoform NNOS Mu may be an effector enzyme for the dystrophin complex. {ECO:0000269|PubMed:17293453}.
Subcellular Location	Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed in the nervous system: expressed in cerebrum, olfactory bulb, hippocampus, midbrain, cerebellum, pons, medulla oblongata, and spinal cord. Also found in skeletal muscle, where it is localized beneath the sarcolemma of fast twitch muscle fibers, and in spleen, heart, kidney, and liver. N-NOS-1 and N-NOS-2 are found in all parts of the nervous system. NNOS beta and gamma occur in a region-specific manner in the brain and NNOS beta expression is developmentally regulated. NNOS Mu is only found in mature skeletal and cardiac muscles.
Top Pathways	Circadian entrainment, Phagosome, Salivary secretion, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

nNOS Antibody - NB120-3511 from Novus Biologicals Prices $299.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

uNOS Antibody (NOS-3F7-B11 B5) - NB120-2801 from Novus Biologicals Prices $299.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone NOS-3F7-B11 B5

nNOS Antibody - NBP1-97555 from Novus Biologicals Prices $279.00, $399.00 Sizes 50 µg, 200 µg Host Rabbit Clonality Polyclonal

Monoclonal Anti-Nitric Oxide Synthase, Universal antibody produced in mouse - N218 from Sigma-Aldrich Prices $383.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone NOS-3F7-B11-B5

nNOS (Ab-847) Antibody (OAEC00504) - OAEC00504 from Aviva Systems Biology Prices $229.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

nNOS antibody - 70R-35631 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

NOS1 Antibody (OAED00090) - OAED00090 from Aviva Systems Biology Prices $185.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

nNOS antibody - 70R-37595 from Fitzgerald Prices $225.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

nNOS antibody (Ser852) - 70R-35763 from Fitzgerald Host Rabbit Clonality Polyclonal

NOS1 Antibody - abx103473 from Abbexa Host Rabbit Clonality Polyclonal

NOS1 Antibody - abx103474 from Abbexa Host Rabbit Clonality Polyclonal

NOS1 Antibody - abx103475 from Abbexa Host Rabbit Clonality Polyclonal

NOS1 antibody - SP5403 from Acris Antibodies Prices $450.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NOS1 antibody - PAB11714 from Acris Antibodies Prices $420.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NOS1 / bNOS (+ iNOS + eNOS) antibody - SP5118P from Acris Antibodies Prices $450.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Goat Anti-Human nNOS - DS-PB-01464 from RayBiotech Host Goat

Anti-Nitric Oxide Synthase 1, Neuronal (NOS1) - 20-3214 from ARP American Research Products Prices $279.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Nitric Oxide Synthase 1, Neuronal (NOS1) - 20-3215 from ARP American Research Products Prices $279.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Nitric Oxide Synthase 1, Neuronal (NOS1) - 20-3216 from ARP American Research Products Prices $279.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

nNOS (Ab-847) Antibody - E021159-1 from Enogene Prices $100.00 Sizes 50μg/50μl Host Rabbit

nNOS (Ab-847) Antibody - E021159-2 from Enogene Prices $170.00 Sizes 100μg/100μl Host Rabbit

Rabbit anti-Mouse nNOS (neuronal) (phospho S847) polyclonal antibody - DPABH-27418 from Creative Diagnostics Host Rabbit Clonality Polyclonal

APC Anti-Mouse LPAM-1 (DATK32) - 20-5887 from Tonbo Biosciences Prices $57.00, $156.00 Sizes 25 µg, 100 µg Clone DATK32

FITC Anti-Mouse CD3 (17A2) - 35-0032 from Tonbo Biosciences Prices $19.00, $52.00 Sizes 25 µg, 100 µg Clone 17A2

In Vivo Ready™ Anti-Mouse IL-10 (JES5-2A5) - 40-7102 from Tonbo Biosciences Prices $59.00, $178.00 Sizes 100 µg, 500 µg Clone JES5-2A5

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