Flt1
| Gene Symbol | Flt1 |
|---|---|
| Entrez Gene | 54251 |
| Alt Symbol | VEGFR-1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | FMS-related tyrosine kinase 1 |
| Other Description | FLT-1|FMS-like tyrosine kinase 1|Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular endothelial growth factor receptor-1 |
| Swissprots | P53767 |
| Accessions | EDL89555 EDL89556 P53767 AF157595 AAF80356 D28498 BAA05857 XM_008768998 XP_008767220 NM_019306 NP_062179 |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers wi |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endosome {ECO:0000250}. Note=Autophosphorylation promotes ubiquitination and endocytosis. {ECO:0000250}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway |
VEGFR1 Polyclonal Antibody - bs-0170R from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0170R-A350 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-0170R-A488 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-0170R-A555 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-0170R-A647 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, Cy3 Conjugated - bs-0170R-Cy3 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, Cy5 Conjugated - bs-0170R-Cy5 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, Cy5.5 Conjugated - bs-0170R-Cy5.5 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, Cy7 Conjugated - bs-0170R-Cy7 from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, FITC Conjugated - bs-0170R-FITC from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, Biotin Conjugated - bs-0170R-Biotin from Bioss
|
||||||||
VEGFR1 Polyclonal Antibody, HRP Conjugated - bs-0170R-HRP from Bioss
|
||||||||
FLT1 antibody - GTX12263 from GeneTex
|
||||||||
FLT1 Antibody (OABF00083) - OABF00083 from Aviva Systems Biology
|
||||||||
Anti -FLT1 (r.FLT1, Fms-like tyrosine kinase 1) - 145115 from USBiological Life Science
|
||||||||
FLT1 Antibody - abx112564 from Abbexa
|
||||||||
Anti-FLT1 - 10-P1966-1-1 from ARP American Research Products
|
||||||||
Anti-VEGF Receptor 1 Antibody - 10-P1966-1 from ARP American Research Products
|
||||||||
Anti-Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - 20-4145 from ARP American Research Products
|
||||||||
FLT1/VEGFR1 Polyclonal Antibody - PA000099-PA1966 from Syd Labs
|
||||||||
VEGF Receptor 1, Polyclonal Antibody - MBS176292 from MyBioSource
|
||||||||
Anti-VEGFR1/FLT1 Antibody PA1966-1 - PA1966-1 from Boster Bio
|
||||||||
FLT1 Antibody - CSB-PA008732GA01HU from Cusabio
|
||||||||
Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - MAB818Ra21 from Cloud-clone
|
||||||||
Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - PAB818Ra01 from Cloud-clone
|