Flt1

Gene Symbol	Flt1
Entrez Gene	54251
Alt Symbol	VEGFR-1
Species	Rat
Gene Type	protein-coding
Description	FMS-related tyrosine kinase 1
Other Description	FLT-1|FMS-like tyrosine kinase 1|Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular endothelial growth factor receptor-1
Swissprots	P53767
Accessions	EDL89555 EDL89556 P53767 AF157595 AAF80356 D28498 BAA05857 XM_008768998 XP_008767220 NM_019306 NP_062179
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers wi
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endosome {ECO:0000250}. Note=Autophosphorylation promotes ubiquitination and endocytosis. {ECO:0000250}.
Top Pathways	Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat VEGFR1 protein (His Tag) - orb139866 from Biorbyt Category Protein Prices $298.00, $400.00 Sizes 50 μg, 100 μg Source Human Cells Species Rat

Rat VEGFR1 Protein - abx069647 from Abbexa Category Protein Source E.coli Species Rat

Vascular Endothelial Growth Factor Receptor 1 - 20-8053 from ARP American Research Products Category Protein Prices $329.00 Sizes 50 µg Source E.coli Species Rat

Recombinant Rat Flt1, His tagged - Flt1-8712R from Creative Biomart Category Protein Source Human Cells Species Rat

Rat VEGFR1 / FLT-1 Protein (His Tag) - 80101-R08H-50 from Sino Biological Category Protein Prices $108.00, $178.00 Sizes 50 µg, 100 µg Source Human Cells Species Rat

Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - RPB818Ra01 from Cloud-clone Category Protein Source E.coli Species Rat

Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - RPB818Ra02 from Cloud-clone Category Protein Source E.coli Species Rat

Recombinant Rat Vascular endothelial growth factor receptor 1(Flt1) - CSB-YP008732RA CSB-EP008732RA CSB-BP008732RA CSB-MP008732RA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Rat

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - RPU144331 from Biomatik Category Protein Prices $143.00, $286.00, $429.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Rat

Vascular Endothelial Growth Factor Receptor 1 Protein (Recombinant) - abx167570 from Abbexa Category Protein Source Rat Species Rat

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), Recombinant Protein - MBS2011780 from MyBioSource Category Protein Prices $175.00, $275.00, $395.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Vascular endothelial growth factor receptor 1(Flt1) , Recombinant Protein - MBS966980 from MyBioSource Category Protein Prices $2,660.00, $2,660.00, $3,080.00, $3,080.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Rat

Recombinant Rat VEGFR1 / FLT-1 Protein (His tag) - PKSR030362 from Elabscience Category Protein Source Human Cell Species Rat

Recombinant Rat FLT1 Protein - FLT1-2364R from Creative Biomart Category Protein Source Mammalian Cells Species Rat

Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - RPU44331 from Biomatik Category Protein Prices $135.00, $260.00, $374.00, $447.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Rat

Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - RPU51530 from Biomatik Category Protein Prices $176.00, $360.00, $550.00, $656.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Rat

FLT1 Recombinant Protein (OPCD07900) - OPCD07900 from Aviva Systems Biology Category Protein Source E.coli Species Rat

FLT1 Recombinant Protein (OPCD07904) - OPCD07904 from Aviva Systems Biology Category Protein Source E.coli Species Rat

Rat VEGFR1 / FLT-1 Protein (His Tag) - 80101-R08H from ABclonal Category Protein Prices $108.00, $178.00 Sizes 50 µg, 100 µg Source Human Cells Species Rat

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