Gene Symbol | Flt1 |
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Entrez Gene | 54251 |
Alt Symbol | VEGFR-1 |
Species | Rat |
Gene Type | protein-coding |
Description | FMS-related tyrosine kinase 1 |
Other Description | FLT-1|FMS-like tyrosine kinase 1|Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular endothelial growth factor receptor-1 |
Swissprots | P53767 |
Accessions | EDL89555 EDL89556 P53767 AF157595 AAF80356 D28498 BAA05857 XM_008768998 XP_008767220 NM_019306 NP_062179 |
Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers wi |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endosome {ECO:0000250}. Note=Autophosphorylation promotes ubiquitination and endocytosis. {ECO:0000250}. |
Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway |
Vascular�Endothelial�Growth�Factor�Receptor 1�ELISA�Kit, FLT1/VEGFR1, Rat, ELISA Kit - E-EL-R0911 from ARP American Research Products
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Vascular endothelial cell growth factor receptor 1, VEGFR-1/Flt1, Rat, ELISA Kit - CSB-E07350r from ARP American Research Products
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Vascular endothelial growth factor receptor 1 (FLT1), Rat, ELISA Kit - E02V0060 from ARP American Research Products
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Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), Rat, ELISA Kit - SEB818Ra from ARP American Research Products
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Vascular endothelial growth factor receptor 1, Flt1, Rat, ELISA Kit - E0147r from ARP American Research Products
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Vascular endothelial growth factor receptor 1, Rat, ELISA Kit - E02V0019 from ARP American Research Products
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Vascuoar Endothelial Cell Growth Factor Receptor 1, VEGFR-1/Flt1, Rat, ELISA Kit - YHB1132Ra from ARP American Research Products
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Vascuoar Endothelial Cell Growth Factor Receptor 2, VEGFR-2/Flt1, Rat, ELISA Kit - YHB1133Ra from ARP American Research Products
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Rat VEGFR-1/Flt1 ELISA Kit - RV0045 from NeoScientific
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VEGF-R1, ELISA Kit - MBS355297 from MyBioSource
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Rat FLT1/VEGFR1(Vascular Endothelial Growth Factor Receptor 1) ELISA Kit - E-EL-R0911 from Elabscience
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Rat FLT1/VEGFR1 (Vascular Endothelial Growth Factor Receptor 1) CLIA Kit - E-CL-R0616 from Elabscience
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fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , ELISA Kit - MBS704848 from MyBioSource
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Vascuoar endothelial cell growth factor receptor 2, VEGFR-2/Flt1, ELISA Kit - MBS9301252 from MyBioSource
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Rat Vascular endothelial cell growth factor receptor 1,VEGFR-1/Flt1 ELISA Kit - CSB-E07350r from Cusabio
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Rat Vascular endothelial growth factor receptor 1 ELISA - E02V0019 from BlueGene Biotech
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ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) - SEB818Ra from Cloud-clone
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Rat Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) ELISA Kit - EKU08105 from Biomatik
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Rat FLT1/VEGFR1(Vascular Endothelial Growth Factor Receptor 1) ELISA Kit - E-EL-R0911 from Iwai North America Inc.
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Rat FASN (Fatty Acid Synthase) CLIA Kit - E-CL-R0259 from Iwai North America Inc.
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Rat FLT1/VEGFR1 (Vascular?Endothelial?Growth?Factor?Receptor 1)?CLIA?Kit? - E-CL-R0616 from Iwai North America Inc.
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Rat Fms-Like Tyrosine Kinase 1 ELISA Kit - abx055190 from Abbexa
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Rat VEGFR1 ELISA Kit - abx156223 from Abbexa
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Vascular Endothelial Growth Factor Receptor 1 (VEGFR1), Rat, ELISA Kit - DL-VEGFR1-Ra from ARP American Research Products
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Rat Vascular endothelial growth factor receptor 1 ELISA Kit - abx255660 from Abbexa
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