| Gene Symbol |
Flt1
|
| Entrez Gene |
54251
|
| Alt Symbol |
VEGFR-1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
FMS-related tyrosine kinase 1
|
| Other Description |
FLT-1|FMS-like tyrosine kinase 1|Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular endothelial growth factor receptor-1
|
| Swissprots |
P53767
|
| Accessions |
EDL89555 EDL89556 P53767 AF157595 AAF80356 D28498 BAA05857 XM_008768998 XP_008767220 NM_019306 NP_062179
|
| Function |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers wi
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Endosome {ECO:0000250}. Note=Autophosphorylation promotes ubiquitination and endocytosis. {ECO:0000250}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway
|