FLT3

Gene Symbol FLT3
Entrez Gene 2322
Alt Symbol CD135, FLK-2, FLK2, STK1
Species Human
Gene Type protein-coding
Description fms-related tyrosine kinase 3
Other Description CD135 antigen|FL cytokine receptor|fetal liver kinase 2|fms-like tyrosine kinase 3|growth factor receptor tyrosine kinase type III|receptor-type tyrosine-protein kinase FLT3|stem cell tyrosine kinase 1
Swissprots F5H0A0 B7ZLT7 P36888 Q13414 A0AVG9 B7ZLT8
Accessions AAB52916 CEO43471 EAX08424 EAX08425 P36888 AW057705 AW772610 BC036028 BC126350 AAI26351 BC144039 AAI44040 BC144040 AAI44041 BI461248 L36162 AAA35487 U02687 AAA18947 Z26652 CAA81393 XM_011535015 XP_011533317 XM_011535016 XP_011533318 XM_011535017 XP_011533319 XM_011535018 XP_011533320 NM_004119 NP_004110 NR_130706
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:2126
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Tissue Specificity Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia. {ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:7507245, ECO:0000269|PubMed:8394751, ECO:0000269|PubMed:8637232}.
Top Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Acute myeloid leukemia, Central carbon metabolism in cancer, Transcriptional misregulation in cancer

Flt3 / CD135 protein (Fc Chimera Active) - ab83998 from Abcam

Category Protein
Prices $302.00
Sizes 25 µg
Source HEK 293 cells
Species Human
Densitometry of protein isoforms visualised by 2-DE. The densitometry scan demonstrates the purified human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein.

Active human Flt3 / CD135 protein fragment - ab55709 from Abcam

Category Protein
Prices $302.00
Sizes 10 µg
Source Insect cells
Species Human
Kinase activity plot using ab55709. Specific activity: 70 nmol/min/mg.

Active human Flt3 / CD135 protein fragment - ab42610 from Abcam

Category Protein
Prices $326.00
Sizes 10 µg
Species Human

Active human Flt3 / CD135 protein fragment - ab73449 from Abcam

Category Protein
Prices $257.00
Sizes 10 µg
Source Insect cells
Species Human

Flt3 / CD135 (phospho Y591) peptide - ab179558 from Abcam

Category Peptide
Prices $176.00
Sizes 100 µg

Human Flt3 / CD135 peptide - ab68602 from Abcam

Category Peptide

Human Flt3 / CD135 protein fragment - ab59307 from Abcam

Category Protein
Source E. coli
Species Human

Mouse Flt3 / CD135 protein fragment - ab59308 from Abcam

Category Protein
Source NSO cells
Species Mouse

CD135 / FLT3 Antibody Blocking Peptide - LS-E3442 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CD135 / FLT3 Antibody Blocking Peptide - LS-E31331 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

CD135 / FLT3 Antibody Blocking Peptide - LS-E9145 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CD135 / FLT3 Antibody Blocking Peptide - LS-E9146 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CD135 / FLT3 Antibody Blocking Peptide - LS-E29230 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

CD135 / FLT3 Antibody Blocking Peptide - LS-E29231 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

CD135 / FLT3 Antibody Blocking Peptide - LS-E29232 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human Flt-3/Flk-2/CD135 Protein - H00002322-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Source Wheat Germ
Species Human

Recombinant Human Flt-3/Flk-2/CD135 Protein - P4695 from Novus Biologicals

Category Protein
Prices $1,559.00
Sizes 100 µg
Source Insect
Species Human

Flt-3/Flk-2/CD135 Peptide - P2672 from Novus Biologicals

Category Peptide
Species Human

Flt-3/Flk-2/CD135 Peptide - P2671 from Novus Biologicals

Category Peptide
Species Human

FLT3-Tyr589591-Antibody-Blocking-peptide - BP11143a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

FLT3-CD135-Antibody-C-term-Blocking-peptide - BP7644b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

FLT3-CD135-Antibody-N-term-Blocking-peptide - BP7644a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human Flt-3/Flk-2 Fc Chimera - 368-ST-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

Recombinant Human Flt-3/Flk-2 Fc Chimera, CF - 368-ST-050/CF from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived

Human Flt3-Ligand Protein (OPMA04599) - OPMA04599 from Aviva Systems Biology

Category Protein
Prices $265.00
Sizes 10 µg
Source E. coli
Species Human
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