Il1r2

Gene Symbol Il1r2
Entrez Gene 16178
Alt Symbol CD121b, Il1r-2
Species Mouse
Gene Type protein-coding
Description interleukin 1 receptor, type II
Other Description CD121 antigen-like family member B|IL-1 receptor beta chain|IL-1 type II receptor|IL-1R-2|IL-1R-beta|IL-1RT-2|IL-1RT2|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II
Swissprots P27931
Accessions EDL14570 EDL14571 P27931 AK132264 BAE21067 BC032962 AAH32962 CT010182 CAJ18390 X59769 CAA42440 XM_006495724 XP_006495787 XM_006495725 XP_006495788 XM_006495726 XP_006495789 XM_011238437 XP_011236739 XM_011238438 XP_011236740 XM_011238439 XP_011236741 XM_011238440 XP_011236742 NM_010555 NP_034685
Function Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}. Secreted {ECO:0000250}.
Tissue Specificity Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1. {ECO:0000269|PubMed:15986350}.
Top Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection

IL-1 RII Antibody (RM0014-7D7) - NB110-85472 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM0014-7D7
Immunohistochemistry-Paraffin: IL-1 RII Antibody (RM0014-7D7) [NB110-85472] - IL1RII immunohistochemistry staining of paraffin sections of mouse Spleen and liver tissues from LPS exposed animals.

IL-1 R2, Monoclonal Antibody - MBS690331 from MyBioSource

Prices $460.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone (7D7)

BD Pharmingen™ PE Rat Anti-Mouse CD121b - 554450 from BD Biosciences

Prices $333.00
Sizes 200 µg
Host Rat
Clonality Monoclonal
Clone 4E2

BD Horizon™ BV421 Rat Anti-Mouse CD121b - 562926 from BD Biosciences

Prices $255.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 4E2

IL-1R2 / CD121b Antibody, Rabbit PAb - 51090-RP01-200 from Sino Biological

Prices $99.00, $99.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

IL-1R2 / CD121b Antibody, Rabbit PAb, Antigen Affinity Purified - 51090-T16-100 from Sino Biological

Prices $99.00, $99.00, $99.00
Sizes 50 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

IL-1R2 recombinant antibody - rec10015 from Covalab

Host Mouse
Clone Praxy-1-1

Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) - PAA065Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) - PAA065Mu02 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Functional-IL-1R2-mouse-Antibody-mAb-recombinant - ADP0040 from Abgent, a WuXi AppTec company

Prices $300.00
Sizes 100 µg
Clonality Monoclonal
Clone Praxy-1-1
Detection of endogenous mouse IL-1R2 with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) . Method: In vitro-cultivated BMN (mouse Neutrophils) (stimulated 24h with hydrocortisone) were stained with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) (thick green line) or an isotype control (thin black line) at 5ug/ml each, revealed with a secondary anti-mouse antibody (FITC) and then analyzed by flow cytometry.

Recombinant Mouse Anti-Mouse Il1R2 Antibody,clone Praxy-1 - DrMAB-1012 from Creative Biolabs

Host Mouse
Clone Praxy-1

Recombinant Human AntiIL-Mouse Il1r2 Antibody, clone Praxy-1-1 - DrMAB-1081 from Creative Biolabs

Host Human
Clone Praxy-1-1

IL-1R2 / CD121b Antibody, Rabbit PAb - 51090-RP01-400 from Sino Biological

Host Rabbit
Clonality Polyclonal
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