Il1r2

Gene Symbol	Il1r2
Entrez Gene	16178
Alt Symbol	CD121b, Il1r-2
Species	Mouse
Gene Type	protein-coding
Description	interleukin 1 receptor, type II
Other Description	CD121 antigen-like family member B|IL-1 receptor beta chain|IL-1 type II receptor|IL-1R-2|IL-1R-beta|IL-1RT-2|IL-1RT2|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II
Swissprots	P27931
Accessions	EDL14570 EDL14571 P27931 AK132264 BAE21067 BC032962 AAH32962 CT010182 CAJ18390 X59769 CAA42440 XM_006495724 XP_006495787 XM_006495725 XP_006495788 XM_006495726 XP_006495789 XM_011238437 XP_011236739 XM_011238438 XP_011236740 XM_011238439 XP_011236741 XM_011238440 XP_011236742 NM_010555 NP_034685
Function	Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). {ECO:0000250}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}. Secreted {ECO:0000250}.
Tissue Specificity	Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1. {ECO:0000269|PubMed:15986350}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse IL1R2 protein - orb139161 from Biorbyt Category Protein Prices $323.00, $434.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

Mouse IL1R2 protein (His Tag) - orb139162 from Biorbyt Category Protein Prices $570.00, $859.00 Sizes 100 μg, 200 μg Source Human Cells Species Mouse

Recombinant Mouse Il1r2, Fc tagged - Il1r2-8699M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse Il1r2, His tagged - Il1r2-8700M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse Interleukin 1 Receptor, Type II - Il1r2-1754M from Creative Biomart Category Protein Source Sf 21 Insect Cells .

Mouse IL-1 receptor type II Recombinant (CD121b) - RKP27931 from Reprokine Category Protein Prices $160.00, $550.00, $2,150.00 Sizes 50 µg, 200 µg, 1 mg Source Optimized DNA sequence encoding Mouse extracellular domain of mouse IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells. Species Mouse

Mouse IL1R2 / CD121b Protein (Fc Tag) - 51090-M02H-50 from Sino Biological Category Protein Prices $138.00, $198.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Mouse IL1R2 / CD121b Protein (His Tag) - 51090-M08H-100 from Sino Biological Category Protein Prices $198.00, $348.00 Sizes 100 µg, 200 µg Source Human Cells Species Mouse

Recombinant Interleukin 1 Receptor Type II (IL1R2) - RPA065Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Interleukin 1 Receptor Type II (IL1R2) - RPA065Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Interleukin-1 receptor type 2(Il1r2) - CSB-YP011622MO CSB-EP011622MO CSB-BP011622MO CSB-MP011622MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse IL1R2 / CD121b Protein (His tag) - PKSM040367 from Elabscience Category Protein Source Human Cells Species Mouse

Recombinant Mouse IL1R2 / CD121b Protein (Fc tag) - PKSM040368 from Elabscience Category Protein Source Human Cells Species Mouse

Mouse IL-1 Receptor Type 2 protein - orb334387 from Biorbyt Category Protein Prices $264.00, $451.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Mouse

Mouse IL-1R-2 protein - orb371812 from Biorbyt Category Protein Prices $264.00, $451.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Mouse

Mouse IL1R2 / CD121b Protein (Fc Tag) - 51090-M02H from ABclonal Category Protein Prices $138.00, $198.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Mouse IL1R2 / CD121b Protein (His Tag) - 51090-M08H from ABclonal Category Protein Prices $198.00, $348.00 Sizes 100 µg, 200 µg Source Human Cells Species Mouse

IL-1 RII Recombinant Protein - 92-721 from ProSci Category Protein Prices $315.00 Sizes 50 µg Source Human Cells Species Mouse

IL-1 receptor type II (CD121b) , Recombinant Protein - MBS553264 from MyBioSource Category Protein Prices $220.00, $655.00, $2,525.00 Sizes 50 µg, 200 µg, 1 mg Source HEk293 Cells

IL1R2 / CD121b, Recombinant Protein - MBS2546670 from MyBioSource Category Protein Prices $525.00, $905.00 Sizes 100 µg, 200 µg Source Human Cells

IL1R2 / CD121b, Recombinant Protein - MBS2546671 from MyBioSource Category Protein Prices $375.00, $525.00 Sizes 50 µg, 100 µg Source Human Cells

Interleukin-1 receptor type 2, Recombinant Protein - MBS7042903 from MyBioSource Category Protein Prices $1,200.00, $2,190.00, $3,395.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Mouse

Interleukin-1 receptor type 2 (Il1r2), Recombinant Protein - MBS954092 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Mouse IL-1 Receptor Type 2,IL-1 RII (C-6His) - AP76317 from Signalway Antibody Category Protein Prices $269.00, $479.00, $2,289.00, $3,209.00 Sizes 10 µg, 50 µg, 500 µg, 1 mg Source Human cells Species Mouse

Recombinant Mouse IL-1 Receptor Type 2,IL-1R-2 (C-Fc) - AP76321 from Signalway Antibody Category Protein Prices $269.00, $479.00, $2,289.00, $3,209.00 Sizes 10 µg, 50 µg, 500 µg, 1 mg Source Human Cells Species Mouse

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