| Gene Symbol | Il1r2 |
|---|---|
| Entrez Gene | 16178 |
| Alt Symbol | CD121b, Il1r-2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor, type II |
| Other Description | CD121 antigen-like family member B|IL-1 receptor beta chain|IL-1 type II receptor|IL-1R-2|IL-1R-beta|IL-1RT-2|IL-1RT2|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II |
| Swissprots | P27931 |
| Accessions | EDL14570 EDL14571 P27931 AK132264 BAE21067 BC032962 AAH32962 CT010182 CAJ18390 X59769 CAA42440 XM_006495724 XP_006495787 XM_006495725 XP_006495788 XM_006495726 XP_006495789 XM_011238437 XP_011236739 XM_011238438 XP_011236740 XM_011238439 XP_011236741 XM_011238440 XP_011236742 NM_010555 NP_034685 |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}. Secreted {ECO:0000250}. |
| Tissue Specificity | Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1. {ECO:0000269|PubMed:15986350}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection |