AAK1

Gene Symbol AAK1
Entrez Gene 22848
Alt Symbol -
Species Human
Gene Type protein-coding
Description AP2 associated kinase 1
Other Description AP2-associated protein kinase 1|adaptor-associated kinase 1
Swissprots Q4ZFZ3 Q2M2I8 Q9UPV4 Q53RX6
Accessions AAX88861 AAY14931 EAW99847 EAW99848 Q2M2I8 AB028971 BAA83000 AF090100 AF090101 AK055622 AK056043 AK074292 AK098797 AK124872 AK127187 BAC86877 AK310951 AW451954 AW969393 BC002695 AAH02695 BC073953 BC090950 BC104842 AAI04843 BC111965 AAI11966 BC132937 BC132939 BC143710 AAI43711 BX640963 BX641060 CA436375 DA121999 DB285703 NM_014911 NP_055726
Function Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. {ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity). {ECO:0000250}.
Tissue Specificity Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain. {ECO:0000269|PubMed:17494869}.

Mouse/Human/Rat AAK1 ELISA Kit (Cell-Based ELISA) - LS-F3224 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

AP2-associated protein kinase 1 (AAK1), Human, ELISA Kit - E01A1119 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

AAK1 Colorimetric Cell-Based ELISA - CB6045 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

AP2 associated kinase 1, ELISA Kit - MBS9334043 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2 associated protein kinase 1 (AAK1), ELISA Kit - MBS7229198 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7229960 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7239196 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7208749 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7217966 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7209314 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7214465 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7229849 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7222194 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7251394 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7251690 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AP2-associated protein kinase 1 (AAK1), ELISA Kit - MBS7211003 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AAK1 ELISA Kit - DEIA-XYA145 from Creative Diagnostics

Category ELISA Kit

Human AAK1 ELISA Kit - E003191 from Biobool

Category ELISA Kit

anti-AAK1 antibody - ARG65033 from Arigo Biolaboratories

Category ELISA Kit

AAK1 Colorimetric Cell-Based ELISA Kit - EKA50874 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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