| Gene Symbol |
AAK1
|
| Entrez Gene |
22848
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
AP2 associated kinase 1
|
| Other Description |
AP2-associated protein kinase 1|adaptor-associated kinase 1
|
| Swissprots |
Q4ZFZ3 Q2M2I8 Q9UPV4 Q53RX6
|
| Accessions |
AAX88861 AAY14931 EAW99847 EAW99848 Q2M2I8 AB028971 BAA83000 AF090100 AF090101 AK055622 AK056043 AK074292 AK098797 AK124872 AK127187 BAC86877 AK310951 AW451954 AW969393 BC002695 AAH02695 BC073953 BC090950 BC104842 AAI04843 BC111965 AAI11966 BC132937 BC132939 BC143710 AAI43711 BX640963 BX641060 CA436375 DA121999 DB285703 NM_014911 NP_055726
|
| Function |
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. {ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain. {ECO:0000269|PubMed:17494869}.
|