MAP3K14

Gene Symbol MAP3K14
Entrez Gene 9020
Alt Symbol FTDCR1B, HS, HSNIK, NIK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 14
Other Description NF-kappa-beta-inducing kinase|serine/threonine-protein kinase NIK
Swissprots D3DX67 A8K2D8 Q8IYN1 Q99558
Accessions ABC40733 EAW51529 EAW51530 Q99558 AA564389 AJ008135 AJ008136 AJ008137 AJ008138 AJ008139 AJ008140 AJ008141 AJ008142 AJ008143 AJ008144 AJ008145 AJ008146 AJ008147 AJ008148 AJ008149 AJ008150 AJ008151 AJ008152 AJ008153 AJ008156 AJ008157 AJ008158 AJ008159 AJ008160 AJ008161 AJ008162 AJ008163 AK123696 AK131438 BAD18584 AK290203 BAF82892 AK313085 BC022296 BC035576 AAH35576 BE645094 BU623799 CR749592 CAH18391 DA856801 DQ894064 ABM84990 HY096069 HY287427 Y10256 CAA71306 XM_011525441 XP_011523743 XR_934591 XR_951536 XR_952490 NM_003954 NP_003945
Function Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608}.
Subcellular Location Cytoplasm.
Tissue Specificity Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon. {ECO:0000269|PubMed:9020361}.
Top Pathways TNF signaling pathway, Apoptosis, Epstein-Barr virus infection, HTLV-I infection, Osteoclast differentiation

NIK Antibody - 4994 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, untreated or treated with 10uM MG132, using NIK Antibody #4994.

NIK (H-248) - sc-7211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NIK (H-248): sc-7211. Western blot analysis of NIK expression in non-transfected (A) and NIK transfected (B) COS whole cell lysates.

NIK (N-19) - sc-6363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NIK (A-12) - sc-8417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NIK (A-12): sc-8417. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic and membrane staining of cortical cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

NIK (C-20) - sc-6364 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NIK (C-20): sc-6364. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

NIK (Q-20) - sc-6365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NIK (Q-20): sc-6365. Western blot analysis of NIK expression in Jurkat (A), A549 (B), HEK293 (C), Hep G2 (D), THP-1 (E) and NTERA-2 cl.D1 (F) whole cell lysates.

p-NIK (Thr 559) - sc-12957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-NIK (Thr 559)-R: sc-12957-R. Western blot analysis of NIK phosphorylation in untreated (A) and lambda protein phosphatase treated (B) A549 whole cell lysates.

Anti-NFkB Inducing Kinase NIK antibody - ab7204 from Abcam

Prices $392.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFkB Inducing Kinase NIK antibody (ab7204)Lane 1 : macrophages lysateLane 2 : NIK transfected cell lysate

Anti-NFkB Inducing Kinase NIK antibody - ab19144 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NFkB Inducing Kinase NIK antibody (ab19144) at 1/500 dilution + NIK-transfected 293 cell lysate

Anti-NFkB Inducing Kinase NIK antibody - ab37712 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFkB Inducing Kinase NIK antibody (ab37712) at 1/100 dilutionLane 1 : 293 cell lysateLane 2 : rat testis tissue lysate

Anti-NFkB Inducing Kinase NIK antibody - ab8111 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NFkB Inducing Kinase NIK antibody - ab22042 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-NFkB Inducing Kinase NIK antibody (ab22042) at 3 µg/ml (in untransfected 293 cells )Lane 2 : Anti-NFkB Inducing Kinase NIK antibody (ab22042) at 3 µg/ml (in transfected 293 cells)Lane 1 : As aboveLane 2 : As abovePerformed under reducing conditions.

Anti-NFkB Inducing Kinase NIK antibody - N-terminal - ab137671 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFkB Inducing Kinase NIK antibody - N-terminal (ab137671) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-NIK antibody [3H31L48] - ab203568 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Monoclonal
Clone 3H31L48
Lane 1 : anti FLAG tag antibodyLane 2 : Anti-NIK antibody [3H31L48] (ab203568) at 15 µg/mlLane 1 : Flag tagged NIK transfected 293 cell lysateLane 2 : Flag tagged NIK transfected 293 cell lysate

Anti-MAP3K14 Antibody (aa795-953) - LS-C37665 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa931-947) - LS-C262 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa795-953) - LS-C37666 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa687-703) - LS-C765 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NIK in (A) untransfected and (B) transfected 293 cells using antibody at 3 ug/ml.

Anti-MAP3K14 Antibody - LS-C146894 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa931-947) - LS-C189124 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa769-947, clone 12K143) - LS-C182918 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 12K143

Anti-MAP3K14 Antibody (aa927) - LS-C190232 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa651-680, AP) - LS-C215688 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa651-680, APC) - LS-C215690 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K14 Antibody (aa651-680, Biotin) - LS-C215691 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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