Kdr

Gene Symbol Kdr
Entrez Gene 25589
Alt Symbol Vegfr-2
Species Rat
Gene Type protein-coding
Description kinase insert domain receptor
Other Description FLK-1|FLK1 kinase insert domain receptor (VEGF receptor 2)|FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)|fetal liver kinase 1|kinase insert domain protein receptor|protein-tyrosine kinase receptor flk-1|vascular endothelial growth factor receptor 2
Swissprots O08775
Accessions EDL89914 EDL89915 EDL89916 O08775 BC087029 AAH87029 FQ223522 FQ224884 U93306 AAB97508 U93307 AAB97509 NM_013062 NP_037194
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5- trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosito
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35968}. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus. Localized with RAP1A at cell-cell junctions. Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). {ECO:0000250|UniProtKB:P35968}.
Tissue Specificity Expressed in the post-pubertal mammary glands. {ECO:0000269|PubMed:10878616}.
Top Pathways Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

KDR Antibody - abx113376 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) - 20-3765 from ARP American Research Products

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

VEGFR2 / Flk-1 / CD309 / KDR Antibody, Rabbit PAb - 80113-RP01-200 from Sino Biological

Prices $99.00, $99.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

VEGFR2 / Flk-1 / CD309 / KDR Antibody, Rabbit PAb, Antigen Affinity Purified - 80113-T16-50 from Sino Biological

Prices $99.00, $99.00, $99.00
Sizes 50 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

Vascular Endothelial Growth Factor, Mature, Polyclonal Antibody - MBS612096 from MyBioSource

Prices $615.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

KDR Antibody - CSB-PA012145GA01HU from Cusabio

Host Rabbit

anti-VEGFR2 antibody - ARG51075 from Arigo Biolaboratories

Host Rabbit
Clonality Polyclonal
ARG51075 anti-VEGFR2 antibody WB image Western Blot: extracts from SKOV3 cells stained with anti-VEGFR-2 antibody ARG51075 and the same antibody preincubated with blocking peptide.

anti-VEGFR2 antibody - ARG51073 from Arigo Biolaboratories

Host Rabbit
Clonality Polyclonal
ARG51073 anti-VEGFR2 antibody IHC-P image Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-VEGFR-2 antibody ARG51073 (left) or the same antibody preincubated with blocking peptide (right).
ARG51587 anti-VEGFR2 phospho (Tyr1175) antibody IHC-P image Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-VEGFR2 (phospho Tyr1175) antibody ARG51587 (left) or the same antibody preincubated with blocking peptide (right).

anti-FLK-1/KDR/VEGFR-2 antibody - ARG53026 from Arigo Biolaboratories

ARG53026 anti-FLK-1/KDR/VEGFR-2 antibody IHC-P image Immunohistochemistry: Human Placenta stained with ARG53026 anti-VEGFR-2 antibody
ARG53027 anti-FLK-1/KDR/VEGFR-2 antibody (Ready-to-Use) IHC-P image Immunohistochemistry: Human Placenta stained with ARG53027 anti-VEGFR-2 antibody (ready-to-use)

anti-VEGF Receptor 2 antibody - ARG62493 from Arigo Biolaboratories

VEGFR2 / Flk-1 / CD309 / KDR Antibody, Rabbit PAb - 80113-RP01-400 from Sino Biological

Host Rabbit
Clonality Polyclonal

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Polyclonal Antibody - CAU26062 from Biomatik

Prices $115.00, $269.00, $384.00, $614.00
Sizes 10 μg, 50 μg, 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

KDR Polyclonal Antibody - A7695 from ARP American Research Products

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Clonality Polyclonal

Anti-VEGFR2KDR-Antibody - ABO10431 from Abgent, a WuXi AppTec company

Prices $200.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone KDR-1
Search more