Kdr

Gene Symbol	Kdr
Entrez Gene	25589
Alt Symbol	Vegfr-2
Species	Rat
Gene Type	protein-coding
Description	kinase insert domain receptor
Other Description	FLK-1|FLK1 kinase insert domain receptor (VEGF receptor 2)|FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)|fetal liver kinase 1|kinase insert domain protein receptor|protein-tyrosine kinase receptor flk-1|vascular endothelial growth factor receptor 2
Swissprots	O08775
Accessions	EDL89914 EDL89915 EDL89916 O08775 BC087029 AAH87029 FQ223522 FQ224884 U93306 AAB97508 U93307 AAB97509 NM_013062 NP_037194
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5- trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosito
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35968}. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus. Localized with RAP1A at cell-cell junctions. Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). {ECO:0000250|UniProtKB:P35968}.
Tissue Specificity	Expressed in the post-pubertal mammary glands. {ECO:0000269|PubMed:10878616}.
Top Pathways	Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Vascular endothelial cell growth factor receptor 2, VEGFR-2/Flk-1, Rat, ELISA Kit - CSB-E07348r from ARP American Research Products Category ELISA Kit Prices $465.00, $615.00, $616.00, $619.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), Rat, ELISA Kit - SEB367Ra from ARP American Research Products Category ELISA Kit Prices $742.00 Sizes 96 t Sensitivity 0.059ng/mL Range 0.156-10ng/mL

Vascular endothelial growth factor receptor 2, Kdr, Rat, ELISA Kit - E0148r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Vascular Endothelial Growth Factor Receptor 2, Rat, ELISA Kit - E02V0004 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Rat KDR ELISA Kit - RK0018 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

kinase insert domain receptor (a type III receptor tyrosine kinase) , ELISA Kit - MBS705176 from MyBioSource Category ELISA Kit Prices $250.00, $450.00, $640.00, $2,615.00, $4,940.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.39 ng/ml Range 1.56 ng/ml-100 ng/ml

Rat VEGFR-2/KDR(Vascular Endothelial Growth Factor Receptor 2) ELISA Kit - E-EL-R1060 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Rat VEGFR-2/KDR (Vascuoar Endothelial Growth Factor Receptor 2) CLIA Kit - E-CL-R0687 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

VEGFR-2/KDR, ELISA Kit - MBS2503021 from MyBioSource Category ELISA Kit Prices $445.00 Sizes 96 -strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

Rat Vascular endothelial cell growth factor receptor 2,VEGFR-2/Flk-1 ELISA kit - CSB-E07348r from Cusabio Category ELISA Kit Sensitivity 0.39ng/ml Range 1.56 ng/ml-100 ng/ml

Rat Kinase insert Domain Receptor/VEGFR2 ELISA - E02K0011 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) - SEB367Ra from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.265ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA's were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

Rat Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) ELISA Kit - EKU08109 from Biomatik Category ELISA Kit Prices $758.00, $3,336.00, $6,065.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 24.7 pg/mL Range 62.5-4000 pg/mL

Rat VEGFR-2/KDR(Vascular Endothelial Growth Factor Receptor 2) ELISA Kit - E-EL-R1060 from Iwai North America Inc. Category ELISA Kit Prices $495.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Rat VEGFR-2/KDR (Vascuoar Endothelial Growth Factor Receptor 2) CLIA Kit - E-CL-R0687 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Rat VEGFR2 ELISA Kit - abx156224 from Abbexa Category ELISA Kit Range 0.625 ng/ml - 40 ng/ml

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), Rat, ELISA Kit - DL-VEGFR2-Ra from ARP American Research Products Category ELISA Kit Prices $715.00 Sizes 96 t Range 0.156-10 ng/mL

Rat Vascular Endothelial Growth Factor Receptor 2 ELISA Kit - abx256094 from Abbexa Category ELISA Kit Sensitivity 0.094 ng/ml Range 0.156 ng/ml - 10 ng/ml

Rat Vascular endothelial cell growth factor receptor 2, VEGFR-2/Flk-1 ELISA Kit - EKC39866 from Biomatik Category ELISA Kit Prices $625.00, $2,719.00, $5,063.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.39 ng/ml Range 1.56 ng/ml-100 ng/ml

Rat Vascular endothelial growth factor receptor 2 ELISA Kit - EKE51741 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 78-5000 pg/mL

VEGFR-2/KDR - EKR2852 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156--10ng/ml

KDR ELISA Kit (Rat) : 96 Wells (OKEH00246) - OKEH00246 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 39 pg/mL Range 78 - 5,000 pg/mL

Rat Kdr ELISA Kit - E102534 from Biobool Category ELISA Kit

Rat KDR ELISA Kit - ERK0018 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Rat Vascular endothelial growth factor receptor 2 ELISA Kit - EK1387 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 78-5000 pg/mL

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