| Gene Symbol | Kdr |
|---|---|
| Entrez Gene | 25589 |
| Alt Symbol | Vegfr-2 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | kinase insert domain receptor |
| Other Description | FLK-1|FLK1 kinase insert domain receptor (VEGF receptor 2)|FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)|fetal liver kinase 1|kinase insert domain protein receptor|protein-tyrosine kinase receptor flk-1|vascular endothelial growth factor receptor 2 |
| Swissprots | O08775 |
| Accessions | EDL89914 EDL89915 EDL89916 O08775 BC087029 AAH87029 FQ223522 FQ224884 U93306 AAB97508 U93307 AAB97509 NM_013062 NP_037194 |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5- trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosito |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35968}. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus. Localized with RAP1A at cell-cell junctions. Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). {ECO:0000250|UniProtKB:P35968}. |
| Tissue Specificity | Expressed in the post-pubertal mammary glands. {ECO:0000269|PubMed:10878616}. |
| Top Pathways | Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway |