Kdr

Gene Symbol	Kdr
Entrez Gene	25589
Alt Symbol	Vegfr-2
Species	Rat
Gene Type	protein-coding
Description	kinase insert domain receptor
Other Description	FLK-1|FLK1 kinase insert domain receptor (VEGF receptor 2)|FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)|fetal liver kinase 1|kinase insert domain protein receptor|protein-tyrosine kinase receptor flk-1|vascular endothelial growth factor receptor 2
Swissprots	O08775
Accessions	EDL89914 EDL89915 EDL89916 O08775 BC087029 AAH87029 FQ223522 FQ224884 U93306 AAB97508 U93307 AAB97509 NM_013062 NP_037194
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5- trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosito
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35968}. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus. Localized with RAP1A at cell-cell junctions. Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). {ECO:0000250|UniProtKB:P35968}.
Tissue Specificity	Expressed in the post-pubertal mammary glands. {ECO:0000269|PubMed:10878616}.
Top Pathways	Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat KDR protein - orb171522 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Rat

Rat VEGFR2 Protein - abx069652 from Abbexa Category Protein Source E.coli Species Rat

Vascular Endothelial Growth Factor Receptor 2 - 20-7675 from ARP American Research Products Category Protein Prices $329.00 Sizes 50 µg Source E.coli Species Rat

Recombinant Rat Kdr, Fc tagged - KDR-8718R from Creative Biomart Category Protein Source Human Cells Species Rat

Recombinant Rat Kdr, His-tagged - KDR-8719R from Creative Biomart Category Protein Source Human Cells Species Rat

Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag) - 80113-R02H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Rat

Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (His Tag) - 80113-R08H-20 from Sino Biological Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Rat

Recombinant Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) - RPB367Ra01 from Cloud-clone Category Protein Source E.coli Species Rat

Recombinant Rat Vascular endothelial growth factor receptor 2(Kdr) - CSB-YP012145RA CSB-EP012145RA CSB-BP012145RA CSB-MP012145RA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Rat

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) - RPU144336 from Biomatik Category Protein Prices $143.00, $286.00, $429.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Rat

Vascular endothelial growth factor receptor 2 (Kdr) , Recombinant Protein - MBS1262788 from MyBioSource Category Protein Prices $2,670.00, $2,670.00, $3,090.00, $3,090.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Rat

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), Recombinant Protein - MBS2011185 from MyBioSource Category Protein Prices $175.00, $275.00, $395.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Recombinant Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (His tag) - PKSR030128 from Elabscience Category Protein Source Human Cell Species Rat

Recombinant Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc tag) - PKSR030129 from Elabscience Category Protein Source Human Cell Species Rat

Recombinant Rat KDR Protein - KDR-3239R from Creative Biomart Category Protein Source Mammalian Cells Species Rat

Recombinant Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) - RPU44336 from Biomatik Category Protein Prices $172.00, $297.00, $454.00, $567.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Rat

KDR Recombinant Protein (OPCD00110) - OPCD00110 from Aviva Systems Biology Category Protein Source E.coli Species Rat

Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag) - 80113-R02H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Rat

Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (His Tag) - 80113-R08H from ABclonal Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Rat

Recombinant Rat KDR protein, Fc-tagged, APC labeled - KDR-8718RA from Creative Biomart Category Protein Source HEK293 Species Rat

Recombinant Rat KDR protein, Fc-tagged, R-PE labeled - KDR-8718RP from Creative Biomart Category Protein Source HEK293 Species Rat

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