| Gene Symbol |
PVRL4
|
| Entrez Gene |
81607
|
| Alt Symbol |
EDSS1, LNIR, PRR4, nectin-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poliovirus receptor-related 4
|
| Other Description |
Ig superfamily receptor LNIR|nectin 4|nectin-4|poliovirus receptor-related protein 4
|
| Swissprots |
B4DQW3 Q96K15 Q96NY8
|
| Accessions |
CDM63684 CDM63771 CDM63773 CDM63774 CDM63775 CDM63777 CDM63778 EAW52665 EAW52666 Q96NY8 AB105191 BAQ19759 AB755430 BAM65001 AF160477 AAF82399 AF218028 AAG17270 AF426163 AAL23958 AK027753 BAB55344 AK298981 BAG61075 AK301481 BAG62996 BC010423 AAH10423 BC013892 BX641083 CF529301 DB223835 DQ893504 ABM84430 DQ896483 ABM87482 XM_005245508 XP_005245565 XM_011510021 XP_011508323 XM_011510022 XP_011508324 XM_011510023 XP_011508325 NM_030916 NP_112178
|
| Function |
Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with MLLT4 at cadherin-based adherens junctions.
|
| Tissue Specificity |
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. {ECO:0000269|PubMed:11544254, ECO:0000269|PubMed:17474988}.
|
| Top Pathways |
Adherens junction
|
![Western Blot: PVRL4 Overexpression Lysate (Adult Normal) [NBL1-15008] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PVRL4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11960_PVRL4%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-15008-img0002.jpg)