| Gene Symbol | Lnpep |
|---|---|
| Entrez Gene | 240028 |
| Alt Symbol | 2010309L07Rik, 4732490P18Rik, CAP, IRAP, PLAP, gp160, vp165 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | leucyl/cystinyl aminopeptidase |
| Other Description | OTase|cystinyl aminopeptidase|leucyl-cystinyl aminopeptidase|oxytocinase |
| Swissprots | Q8C129 |
| Accessions | EDL20504 Q8C129 AK008544 AK008556 AK029094 BAC26293 AK036967 BAC29651 AK038203 AK089903 AK147232 AK153220 AK155945 AK161484 BAE36417 AK162332 AK164875 AK172174 BAE42865 BC066791 AAH66791 BC120925 AAI20926 BC120926 AAI20927 NM_172827 NP_766415 |
| Function | Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endomembrane system {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration (By similarity). {ECO:0000250}. |
| Top Pathways | Renin-angiotensin system |
Interleukin 1 receptor antagonist, IL-1ra, Mouse, ELISA Kit - CSB-E10395m from ARP American Research Products
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Leucyl-cystinyl aminopeptidase, Lnpep, Mouse, ELISA Kit - E13522m from ARP American Research Products
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Leucyl-Cystinyl aminopeptidase, Mouse, ELISA Kit - E03L0290 from ARP American Research Products
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Serpin B6 (SERPINB6), Mouse, ELISA Kit - CSB-EL021074MO from ARP American Research Products
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Leucyl/Cystinyl Aminopeptidase - MBS094142 from MyBioSource
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Mouse IRAP ELISA Kit - E056193 from Biobool
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Mouse Lnpep ELISA Kit - E058612 from Biobool
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LNPEP ELISA Kit (Mouse) (OKEH05548) - OKEH05548 from Aviva Systems Biology
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Mouse Sorbin and SH3 domain-containing protein 1 (SORBS1) ELISA Kit - AE17725MO from ARP American Research Products
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Leucyl-cystinyl aminopeptidase, ELISA Kit - MBS2887607 from MyBioSource
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