Gene Symbol | Lnpep |
---|---|
Entrez Gene | 240028 |
Alt Symbol | 2010309L07Rik, 4732490P18Rik, CAP, IRAP, PLAP, gp160, vp165 |
Species | Mouse |
Gene Type | protein-coding |
Description | leucyl/cystinyl aminopeptidase |
Other Description | OTase|cystinyl aminopeptidase|leucyl-cystinyl aminopeptidase|oxytocinase |
Swissprots | Q8C129 |
Accessions | EDL20504 Q8C129 AK008544 AK008556 AK029094 BAC26293 AK036967 BAC29651 AK038203 AK089903 AK147232 AK153220 AK155945 AK161484 BAE36417 AK162332 AK164875 AK172174 BAE42865 BC066791 AAH66791 BC120925 AAI20926 BC120926 AAI20927 NM_172827 NP_766415 |
Function | Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endomembrane system {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration (By similarity). {ECO:0000250}. |
Top Pathways | Renin-angiotensin system |
IL 1RA Mouse - CYPS-665 from NeoScientific
|
||||||||||
IL 1RA Mouse, His - CYPS-143 from NeoScientific
|
||||||||||
IL 1RA Mouse - BCA-284 from Reagent Proteins
|
||||||||||
Recombinant Mouse Leucyl-cystinyl aminopeptidase(Lnpep) ,partial - CSB-YP805384MO CSB-EP805384MO CSB-BP805384MO CSB-MP805384MO from Cusabio
|
||||||||||
Recombinant Mouse LNPEP Protein - LNPEP-9167M from Creative Biomart
|
||||||||||
Interleukin-1 Receptor Antagonist Mouse Recombinant - Pr21268 from ProMab
|
||||||||||
Leucyl-cystinyl aminopeptidase (Lnpep), partial, Recombinant Protein - MBS1369095 from MyBioSource
|