Gene Symbol | Lnpep |
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Entrez Gene | 240028 |
Alt Symbol | 2010309L07Rik, 4732490P18Rik, CAP, IRAP, PLAP, gp160, vp165 |
Species | Mouse |
Gene Type | protein-coding |
Description | leucyl/cystinyl aminopeptidase |
Other Description | OTase|cystinyl aminopeptidase|leucyl-cystinyl aminopeptidase|oxytocinase |
Swissprots | Q8C129 |
Accessions | EDL20504 Q8C129 AK008544 AK008556 AK029094 BAC26293 AK036967 BAC29651 AK038203 AK089903 AK147232 AK153220 AK155945 AK161484 BAE36417 AK162332 AK164875 AK172174 BAE42865 BC066791 AAH66791 BC120925 AAI20926 BC120926 AAI20927 NM_172827 NP_766415 |
Function | Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endomembrane system {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration (By similarity). {ECO:0000250}. |
Top Pathways | Renin-angiotensin system |
IRAP CRISPR/Cas9 KO Plasmid (m) - sc-433729 from Santa Cruz Biotechnology
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IRAP HDR Plasmid (m) - sc-433729-HDR from Santa Cruz Biotechnology
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IRAP Double Nickase Plasmid (m) - sc-433729-NIC from Santa Cruz Biotechnology
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IRAP Double Nickase Plasmid (m2) - sc-433729-NIC-2 from Santa Cruz Biotechnology
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IRAP CRISPR Activation Plasmid (m) - sc-433729-ACT from Santa Cruz Biotechnology
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IRAP CRISPR Activation Plasmid (m2) - sc-433729-ACT-2 from Santa Cruz Biotechnology
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IRAP Lentiviral Activation Particles (m) - sc-433729-LAC from Santa Cruz Biotechnology
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IRAP Lentiviral Activation Particles (m2) - sc-433729-LAC-2 from Santa Cruz Biotechnology
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IRAP siRNA (m) - sc-146283 from Santa Cruz Biotechnology
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IRAP shRNA Plasmid (m) - sc-146283-SH from Santa Cruz Biotechnology
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IRAP shRNA (m) Lentiviral Particles - sc-146283-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU204671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34848 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34848 from Sigma-Aldrich
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LNPEP siRNA (Mouse) - CRN3455 from Cohesion Biosciences
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shRNA set against Mouse LNPEP (NM_172827.3) - SHH331191 from Creative biogene
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shRNA set against Mouse Lnpep(NM_172827.3) - SHH152723 from Creative biogene
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Mouse LNPEP siRNA - orb292930 from Biorbyt
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LNPEP shRNA Plasmid (Mouse) - CHN3455 from Cohesion Biosciences
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LNPEP miRNA 3'UTR clone - MiUTR1M-06697 from Creative biogene
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