| Gene Symbol |
Lnpep
|
| Entrez Gene |
240028
|
| Alt Symbol |
2010309L07Rik, 4732490P18Rik, CAP, IRAP, PLAP, gp160, vp165
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
leucyl/cystinyl aminopeptidase
|
| Other Description |
OTase|cystinyl aminopeptidase|leucyl-cystinyl aminopeptidase|oxytocinase
|
| Swissprots |
Q8C129
|
| Accessions |
EDL20504 Q8C129 AK008544 AK008556 AK029094 BAC26293 AK036967 BAC29651 AK038203 AK089903 AK147232 AK153220 AK155945 AK161484 BAE36417 AK162332 AK164875 AK172174 BAE42865 BC066791 AAH66791 BC120925 AAI20926 BC120926 AAI20927 NM_172827 NP_766415
|
| Function |
Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endomembrane system {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration (By similarity). {ECO:0000250}.
|
| Top Pathways |
Renin-angiotensin system
|