ANGPT2

Gene Symbol ANGPT2
Entrez Gene 285
Alt Symbol AGPT2, ANG2
Species Human
Gene Type protein-coding
Description angiopoietin 2
Other Description ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
Swissprots Q9P2Y7 B7ZLM7 Q9NRR7 A0AV38 A8K205 O15123
Accessions AAT69979 CAK96154 EAW80472 EAW80473 EAW80474 O15123 AB009865 BAA95590 AF004327 AAB63190 AF187858 AAF76526 AF218015 AAG17257 AJ289780 CAC08179 AJ289781 CAC08180 AK075219 AK225698 AK290070 BAF82759 AK310171 AK312541 BAG35440 BC022490 BC126200 AAI26201 BC126202 AAI26203 BC143902 AAI43903 DA829327 HQ258258 ADR83012 NM_001118887 NP_001112359 NM_001118888 NP_001112360 NM_001147 NP_001138
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
Subcellular Location Secreted.
Top Pathways PI3K-Akt signaling pathway, Rap1 signaling pathway

Angiopoietin-2 Antibody - 2948 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untransfected or transfected with mouse angiopoietin-2, using Angiopoietin-2 Antibody.

Ang-2 (C-19) - sc-7015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ang-2 (C-19): sc-7015. Western blot analysis of human recombinant Ang-2.

Ang-2 (F-18) - sc-7017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ang-2 (F-18): sc-7017. Western blot analysis of Ang-2 expression in MIA PaCa-2 (A), HUV-EC-C (B), ECV304 (C) and TF-1 (D) whole cell lysates.

Ang-2 (F-1) - sc-74403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ang-2 (F-1): sc-74403. Western blot analysis of human recombinant Ang-2.

Ang-2 (H-11) - sc-74402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ang-2 (H-11): sc-74402. Western blot analysis of Ang-2 expression in HUV-EC-C (A) and TF-1 (B) whole cell lysates.

Ang-2 (H-70) - sc-20718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ang-2 (H-70): sc-20718. Western blot analysis of Ang-2 expression in MM-142 whole cell lysate.

Ang-2 (N-18) - sc-7016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ang-2 (N-18): sc-7016. Immunofluorescence staining of methanol-fixed HEL 92.1.7 cells showing cytoplasmic staining.

Anti-Angiopoietin 2 antibody - ab8452 from Abcam

Prices $390.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Supernatants of mouse angiopoietin-expressing endothelial cells. Soluble Tie 2 was used to precipitate the angiopoietins to reduce background.Lane 1 - mock Lane 2 - mouse angiopoietin-2 (clone 2-9) expressing cells Lane 3 - mouse angiopoietin-1 (clone 1-15) expressing cells Lane 4 - mouse angiopoietin-1 (clone 1-8) expressing cells Lane 5 - wtMarion Scharpfenecker 2002

Anti-Angiopoietin 2 antibody - ab125692 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Angiopoietin 2 antibody (ab125692) at 1 µg/mlLane 2 : Anti-Angiopoietin 2 antibody (ab125692) at 2 µg/mlLane 1 : Human liver tissue lysateLane 2 : Human liver tissue lysateLysates/proteins at 15 µg per lane.

Anti-Angiopoietin 2 antibody - ab10601 from Abcam

Prices $370.00
Sizes 25 µg
Host Goat
Clonality Polyclonal

Anti-Angiopoietin 2 antibody [EPR2891(2)] - ab155106 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2891(2)
ab155106 staining Angiopoietin 2 in Mouse fetal lung tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with formaldehyde, permeabilized with PBST for 1 hour and blocked with 1.5% serum for 20 minutes at 25°C. Samples were incubated with primary antibody (1/500 in PBST) for 12 hours at 4°C. A Biotin-conjugated Goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody.See Abreview

Anti-Angiopoietin 2 antibody [MM0020-1F29] - ab56301 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0020-1F29
ab56301 at 1/200 dilution, staining Angiopoietin 2 in human placental tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-Angiopoietin 2 antibody - C-terminal - ab180820 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Angiopoietin 2 antibody - C-terminal (ab180820) at 1/500 dilution + HepG2 cell lysate

Angiopoietin-2 Antibody [Unconjugated] - AF623 from Novus Biologicals

Prices $99.00, $365.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Angiopoietin-2 Antibody (MM0020-1F29) - NB110-85467 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0020-1F29
Immunocytochemistry/ Immunofluorescence: Angiopoietin-2 Antibody (MM0020-1F29) [NB110-85467] - Staining of frozen human skin sections using Angiopoietin 2 antibody at 1:25 dilution. Image provided via product review by verified customer.

Angiopoietin-2 Antibody (85816) [Unconjugated] - MAB098 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 85816

Angiopoietin-2 Antibody - NBP2-15386 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Angiopoietin 2 Antibody [NBP2-15386] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000.

Angiopoietin-2 Antibody - NBP2-15385 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Angiopoietin-2 Antibody [NBP2-15385] - Mouse lung extracts (50ug) and HUVEC cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Angiopoietin 2 antibody diluted at 1:1000.

Angiopoietin-2 Antibody [Unconjugated] - AB623 from Novus Biologicals

Prices $359.00
Sizes 1 mg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line and Hep3B human hepatocellular carcinoma cell line. PVDF membrane was probed with 2 µg/mL of Goat Anti-Human Angiopoietin‑2 Polyclonal Antibody (Catalog # AB623) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for Angiopoietin‑2 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Angiopoietin-2 Antibody - 18860002 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Angiopoietin 2 Antibody [18860002] Human liver cancer. Hepatocellular carcinomas were distinctly stained with granular appearance in the cytoplasm. Among the other cancer tissues, few showed weak to moderate cytoplasmic immunoreactivity. Most malignancies were unstained (not shown). This image is the courtesy of the Human Proteome Resource (HPR).

Angiopoietin-2 Antibody [Biotin] - BAF623 from Novus Biologicals

Prices $420.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Angiopoietin-2 Antibody (85834) [Biotin] - BAM0981 from Novus Biologicals

Prices $399.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 85834

Angiopoietin 2 Polyclonal Antibody - bs-0677R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat lymphoma tissue labeled Anti-Ang-2/Angiopoietin-2 Polyclonal Antibody, Unconjugated (bs-0677R) at 1:200, followed by conjugation to the secondary antibody and DAB staining

Angiopoietin 2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0677R-A350 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Angiopoietin 2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-0677R-A488 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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