ANGPT2

Gene Symbol	ANGPT2
Entrez Gene	285
Alt Symbol	AGPT2, ANG2
Species	Human
Gene Type	protein-coding
Description	angiopoietin 2
Other Description	ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
Swissprots	Q9P2Y7 B7ZLM7 Q9NRR7 A0AV38 A8K205 O15123
Accessions	AAT69979 CAK96154 EAW80472 EAW80473 EAW80474 O15123 AB009865 BAA95590 AF004327 AAB63190 AF187858 AAF76526 AF218015 AAG17257 AJ289780 CAC08179 AJ289781 CAC08180 AK075219 AK225698 AK290070 BAF82759 AK310171 AK312541 BAG35440 BC022490 BC126200 AAI26201 BC126202 AAI26203 BC143902 AAI43903 DA829327 HQ258258 ADR83012 NM_001118887 NP_001112359 NM_001118888 NP_001112360 NM_001147 NP_001138
Function	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
Subcellular Location	Secreted.
Top Pathways	PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ANGPT2-Over-expression-Lysate - LY12322a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ANGPT2 overexpression lysate - LY426530 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ANGPT2 293 Cell Lysate - 400469 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Angiopoietin-2 Overexpression Lysate (Native) - NBL1-07522 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ANGPT2 Over-expression Lysate Product - GWB-3A9E5E from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Cynomolgus / Rhesus Angiopoietin-2 / ANG2 HEK293 Cell Lysate (WB positive control) - 90026-C07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus Angiopoietin-2 / ANG2 HEK293 Cell Lysate (WB positive control) - 90026-C01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg

Human Angiopoietin-2 / ANG2 HEK293 Cell Lysate (WB positive control) - 10691-H07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human ANG2 / Angiopoietin-2 HEK293 Cell Lysate (WB positive control) - 10691-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Angiopoietin-2 / ANG2 HEK293 Cell Lysate (WB positive control) - 10691-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Angiopoietin-2 Human Cells Transfected Lysate (positive control) (denatured) - orb232841 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human ANG2 Human Cells Transfected Lysate (positive control) (denatured) - orb173525 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human Angiopoietin-2 Human Cells Transfected Lysate (positive control) (denatured) - orb172772 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human ANGPT2 Knockdown Stable Cell Line - CSC-DC000592 from Creative biogene Category Cell Line Species Human

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