ANGPT2

Gene Symbol	ANGPT2
Entrez Gene	285
Alt Symbol	AGPT2, ANG2
Species	Human
Gene Type	protein-coding
Description	angiopoietin 2
Other Description	ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
Swissprots	Q9P2Y7 B7ZLM7 Q9NRR7 A0AV38 A8K205 O15123
Accessions	AAT69979 CAK96154 EAW80472 EAW80473 EAW80474 O15123 AB009865 BAA95590 AF004327 AAB63190 AF187858 AAF76526 AF218015 AAG17257 AJ289780 CAC08179 AJ289781 CAC08180 AK075219 AK225698 AK290070 BAF82759 AK310171 AK312541 BAG35440 BC022490 BC126200 AAI26201 BC126202 AAI26203 BC143902 AAI43903 DA829327 HQ258258 ADR83012 NM_001118887 NP_001112359 NM_001118888 NP_001112360 NM_001147 NP_001138
Function	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
Subcellular Location	Secreted.
Top Pathways	PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Angiopoietin 2 full length protein - ab155606 from Abcam Category Protein Prices $88.00, $176.00, $352.00 Sizes 25 µg, 50 µg, 100 µg Source HEK 293 cells Species Human

Active human Angiopoietin 2 protein fragment - ab123226 from Abcam Category Protein Prices $210.00 Sizes 5 µg Source CHO Species Human

Human Angiopoietin 2 peptide - ab172727 from Abcam Category Peptide Prices $160.00 Sizes 50 µg Species Human

Human Angiopoietin 2 peptide - ab99482 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Angiopoietin 2 protein fragment - ab198435 from Abcam Category Protein Prices $837.00 Sizes 50 µg Source HEK 293 cells Species Human

Mouse Angiopoietin 2 peptide - ab9077 from Abcam Category Peptide Species Mouse

Human Angiopoietin-2 Biologically Active Protein - NBP2-36434 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Angiopoietin-2 Peptide - NBP1-96998 from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg

ANGPT2-Antibody-C-term-Blocking-peptide - BP10103b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Angiopoietin 2 recombinant protein - GTX53817 from GeneTex Category Protein Prices $199.00 Sizes 20 μg Source CHO cells

Recombinant Human Angiopoietin-2 - 623-AN-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr19-Phe496, with a C-terminal 6-His tag

Recombinant Human Angiopoietin-2, CF - 623-AN-01M/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr19-Phe496, with a C-terminal 6-His tag

Recombinant Human Angiopoietin-2, CF - 623-AN-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr19-Phe496, with a C-terminal 6-His tag

Recombinant Human Angiopoietin-2, Biotinylated Protein - BT623 from R&D Systems Category Protein Prices $259.00 Sizes 10 µg Source Mouse myeloma cell line, NS0-derived Tyr19-Phe496, with a C-terminal His tag Species Human

Human Angiopoietin-2 (His Tag) protein - orb232245 from Biorbyt Category Protein Prices $196.00, $323.00, $1,063.00 Sizes 5 μg, 20 μg, 100 μg Species Human

Human ANG2 His tag protein - orb83920 from Biorbyt Category Protein Prices $162.00, $298.00, $434.00 Sizes 5 μg, 20 μg, 50 μg Source Human Species Human

Human Angiopoietin-2 protein - orb245249 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Angiopoietin-2 protein - orb245740 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Canine Angiopoietin-2 (His Tag) protein - orb232675 from Biorbyt Category Protein Prices $196.00, $400.00, $816.00 Sizes 10 μg, 50 μg, 200 μg

Angiopoietin 2 protein - 30R-AA032 from Fitzgerald Category Protein Prices $175.00, $375.00 Sizes 5 µg, 20 µg Source Sf-9 insect cells

Angiopoietin 2 protein - 30R-3254 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

Angiopoietin-2 Blocking Peptide - abx064121 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Monkey, Pig

Human Angiopoietin 2 Protein - abx065321 from Abbexa Category Protein Source E.coli Species Human

Human Angiopoietin 2 Protein - abx065318 from Abbexa Category Protein Source E.coli Species Human

Angiopoietin-2 - AR31000PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source CHO cells Species Human

Search more