ANGPT2

Gene Symbol ANGPT2
Entrez Gene 285
Alt Symbol AGPT2, ANG2
Species Human
Gene Type protein-coding
Description angiopoietin 2
Other Description ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
Swissprots Q9P2Y7 B7ZLM7 Q9NRR7 A0AV38 A8K205 O15123
Accessions AAT69979 CAK96154 EAW80472 EAW80473 EAW80474 O15123 AB009865 BAA95590 AF004327 AAB63190 AF187858 AAF76526 AF218015 AAG17257 AJ289780 CAC08179 AJ289781 CAC08180 AK075219 AK225698 AK290070 BAF82759 AK310171 AK312541 BAG35440 BC022490 BC126200 AAI26201 BC126202 AAI26203 BC143902 AAI43903 DA829327 HQ258258 ADR83012 NM_001118887 NP_001112359 NM_001118888 NP_001112360 NM_001147 NP_001138
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
Subcellular Location Secreted.
Top Pathways PI3K-Akt signaling pathway, Rap1 signaling pathway

Ang-2 CRISPR/Cas9 KO Plasmid (h) - sc-400477 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 HDR Plasmid (h) - sc-400477-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 Double Nickase Plasmid (h) - sc-400477-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 Double Nickase Plasmid (h2) - sc-400477-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 CRISPR Activation Plasmid (h) - sc-400477-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 CRISPR Activation Plasmid (h2) - sc-400477-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 Lentiviral Activation Particles (h) - sc-400477-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 Lentiviral Activation Particles (h2) - sc-400477-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ang-2 siRNA (h) - sc-39305 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ang-2 shRNA Plasmid (h) - sc-39305-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ang-2 shRNA (h) Lentiviral Particles - sc-39305-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU081851 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3147 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3147 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ANGPT2 siRNA (Human) - CRH0198 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ANGPT2 - MBS829897 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ANGPT2 (NM_001147.2) - SHH236238 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ANGPT2(NM_001147.2) - SHG057817 from Creative biogene

Category siRNA
Species Reactivities Human

Human ANGPT2 siRNA - orb260700 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ANGPT2 shRNA Plasmid (Human) - CHH0198 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ANGPT2 miRNA 3'UTR clone - MiUTR1H-00360 from Creative biogene

Species Reactivities Human
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