| Gene Symbol | ANGPT2 |
|---|---|
| Entrez Gene | 285 |
| Alt Symbol | AGPT2, ANG2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | angiopoietin 2 |
| Other Description | ANG-2|Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a |
| Swissprots | Q9P2Y7 B7ZLM7 Q9NRR7 A0AV38 A8K205 O15123 |
| Accessions | AAT69979 CAK96154 EAW80472 EAW80473 EAW80474 O15123 AB009865 BAA95590 AF004327 AAB63190 AF187858 AAF76526 AF218015 AAG17257 AJ289780 CAC08179 AJ289781 CAC08180 AK075219 AK225698 AK290070 BAF82759 AK310171 AK312541 BAG35440 BC022490 BC126200 AAI26201 BC126202 AAI26203 BC143902 AAI43903 DA829327 HQ258258 ADR83012 NM_001118887 NP_001112359 NM_001118888 NP_001112360 NM_001147 NP_001138 |
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}. |
| Subcellular Location | Secreted. |
| Top Pathways | PI3K-Akt signaling pathway, Rap1 signaling pathway |