HLA-DMB

Gene Symbol HLA-DMB
Entrez Gene 3109
Alt Symbol D6S221E, RING7
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class II, DM beta
Other Description HLA class II histocompatibility antigen, DM beta chain|MHC class II HLA-DMB|MHC class II antigen DMB|MHC class II antigen HLA-DM beta chain|class II histocompatibility antigen, M beta chain|really interesting new gene 7 protein
Swissprots Q5SNZ8 Q58ZE2 Q13012 P28068 Q29751 O77936 Q5STC4 Q9XRX2
Accessions AAA03296 AAB61609 AAC26112 AAC50514 AAC50515 AAC50517 AAD30279 AAX84974 AHW47928 AHW47945 AHW47962 AHW47979 CAA54171 CAA60782 EAX03657 P28068 AB209577 BAD92814 AB362554 BAF81534 AB362555 BAF81535 AB362556 BAF81536 AK295872 BAG58670 AK301017 BAG62634 AK315979 BAH14350 AY645722 AAV97947 BC017508 BC027175 AAH27175 BC035650 CD742571 CR407606 CAG28534 DC389968 DQ891141 ABM82067 DQ894320 ABM85246 EL948395 U15085 AAB60387 Z23139 CAA80670 NM_002118 NP_002109
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular Location Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Top Pathways Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

HLA-DMB-Over-expression-Lysate - LY12604a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag HLA-DMB (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HLA-DMB gene

HLA overexpression lysate - LY419522 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

HLA 293 Cell Lysate - 409139 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

HLA DMB Overexpression Lysate (Native) - NBL1-11595 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

HLA-DMβ (h): 293T Lysate - sc-113692 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

HLA Over-expression Lysate Product - GWB-25AAC0 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

HLA DMB Overexpression Lysate (Denatured) - H00003109-T03 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human HLA-DMB Knockdown Stable Cell Line - CSC-DC007088 from Creative biogene

Category Cell Line
Species Human
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