HLA-DMB

Gene Symbol	HLA-DMB
Entrez Gene	3109
Alt Symbol	D6S221E, RING7
Species	Human
Gene Type	protein-coding
Description	major histocompatibility complex, class II, DM beta
Other Description	HLA class II histocompatibility antigen, DM beta chain|MHC class II HLA-DMB|MHC class II antigen DMB|MHC class II antigen HLA-DM beta chain|class II histocompatibility antigen, M beta chain|really interesting new gene 7 protein
Swissprots	Q5SNZ8 Q58ZE2 Q13012 P28068 Q29751 O77936 Q5STC4 Q9XRX2
Accessions	AAA03296 AAB61609 AAC26112 AAC50514 AAC50515 AAC50517 AAD30279 AAX84974 AHW47928 AHW47945 AHW47962 AHW47979 CAA54171 CAA60782 EAX03657 P28068 AB209577 BAD92814 AB362554 BAF81534 AB362555 BAF81535 AB362556 BAF81536 AK295872 BAG58670 AK301017 BAG62634 AK315979 BAH14350 AY645722 AAV97947 BC017508 BC027175 AAH27175 BC035650 CD742571 CR407606 CAG28534 DC389968 DQ891141 ABM82067 DQ894320 ABM85246 EL948395 U15085 AAB60387 Z23139 CAA80670 NM_002118 NP_002109
Function	Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular Location	Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Top Pathways	Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HLA DMB protein fragment - ab158653 from Abcam Category Protein Source Wheat germ Species Human

HLA-DMB Antibody Blocking Peptide - LS-E4270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HLA-DMB Antibody Blocking Peptide - LS-E5525 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HLA-DMB Antibody Blocking Peptide - LS-E23115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HLA DMB Protein - H00003109-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HLA-DMB-Antibody-Center-Blocking-Peptide - BP16546c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HLA-DMB-Antibody-Center-Blocking-Peptide - BP18052c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HLA class II DM beta / HLA-DMB - H00003109-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HLA class II DM beta / HLA-DMB - H00003109-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HLA-DMB fusion protein - ag16320 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

HLA-DMB fusion protein - Ag17507 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human HLA-DMB, GST-tagged - HLA-DMB-13813H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human HLA class II histocompatibility antigen, DM beta chain(HLA-DMB) - CSB-YP333326HU CSB-EP333326HU CSB-BP333326HU CSB-MP333326HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HLA-DMB Protein - abx163217 from Abbexa Category Protein Species Human

HLA class II DM beta / HLA-DMB - TP303811 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HLA DMB Recombinant Protein Antigen - NBP1-85326PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HLA-DMB Peptide, Human - M34GP07088H from Creative Peptides Category Peptide Source Synthetic. Species Human

HLA class II histocompatibility antigen, DM beta chain (HLA-DMB), Recombinant Protein - MBS1096853 from MyBioSource Category Protein Prices $600.00, $750.00, $800.00, $885.00, $900.00, $1,005.00, $1,130.00, $1,140.00, $1,140.00, $1,245.00, $1,635.00, $1,725.00, $1,730.00, $2,185.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 200 µg (Yeast), 100 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HLA class II histocompatibility antigen, DM beta chain (HLA-DMB), Recombinant Protein - MBS7053483 from MyBioSource Category Protein Prices $875.00, $1,370.00, $2,300.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression

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