HLA-DMB

Gene Symbol HLA-DMB
Entrez Gene 3109
Alt Symbol D6S221E, RING7
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class II, DM beta
Other Description HLA class II histocompatibility antigen, DM beta chain|MHC class II HLA-DMB|MHC class II antigen DMB|MHC class II antigen HLA-DM beta chain|class II histocompatibility antigen, M beta chain|really interesting new gene 7 protein
Swissprots Q5SNZ8 Q58ZE2 Q13012 P28068 Q29751 O77936 Q5STC4 Q9XRX2
Accessions AAA03296 AAB61609 AAC26112 AAC50514 AAC50515 AAC50517 AAD30279 AAX84974 AHW47928 AHW47945 AHW47962 AHW47979 CAA54171 CAA60782 EAX03657 P28068 AB209577 BAD92814 AB362554 BAF81534 AB362555 BAF81535 AB362556 BAF81536 AK295872 BAG58670 AK301017 BAG62634 AK315979 BAH14350 AY645722 AAV97947 BC017508 BC027175 AAH27175 BC035650 CD742571 CR407606 CAG28534 DC389968 DQ891141 ABM82067 DQ894320 ABM85246 EL948395 U15085 AAB60387 Z23139 CAA80670 NM_002118 NP_002109
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular Location Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Top Pathways Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

HLA-DMβ siRNA (h) - sc-42911 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLA-DMβ shRNA Plasmid (h) - sc-42911-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLA-DMβ shRNA (h) Lentiviral Particles - sc-42911-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLA DMB RNAi - H00003109-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10130 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10130 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02202 from Sigma-Aldrich

Category miRNA

HLA-DMB siRNA (Human) - CRH2122 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HLA-DMB - MBS828308 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human HLA-DMB siRNA - orb262624 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HLA-DMB shRNA Plasmid (Human) - CHH2122 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HLA-DMB miRNA 3'UTR clone - MiUTR3H-01086 from Creative biogene

Species Reactivities Human
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