| Gene Symbol |
Ada
|
| Entrez Gene |
24165
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
adenosine deaminase
|
| Other Description |
adenosine aminohydrolase
|
| Swissprots |
Q920P6
|
| Accessions |
CBX85548 CBX85616 EDL96561 EDL96562 Q920P6 AB059655 BAB69691 BC088116 AAH88116 NM_130399 NP_569083
|
| Function |
Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:19900420, ECO:0000269|PubMed:8783262}. Cytoplasm {ECO:0000250}. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion. {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain and liver (at protein level). {ECO:0000269|PubMed:19900420, ECO:0000269|PubMed:8783262}.
|
| Top Pathways |
Primary immunodeficiency, Purine metabolism
|
