| Gene Symbol | Ada |
|---|---|
| Entrez Gene | 24165 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | adenosine deaminase |
| Other Description | adenosine aminohydrolase |
| Swissprots | Q920P6 |
| Accessions | CBX85548 CBX85616 EDL96561 EDL96562 Q920P6 AB059655 BAB69691 BC088116 AAH88116 NM_130399 NP_569083 |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:19900420, ECO:0000269|PubMed:8783262}. Cytoplasm {ECO:0000250}. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion. {ECO:0000250}. |
| Tissue Specificity | Detected in brain and liver (at protein level). {ECO:0000269|PubMed:19900420, ECO:0000269|PubMed:8783262}. |
| Top Pathways | Primary immunodeficiency, Purine metabolism |
Adenosine deaminase, Ada, Rat, ELISA Kit - E1390r from ARP American Research Products
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Adenosine Deaminase, Rat, ELISA Kit - E02A0632 from ARP American Research Products
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Dipeptidyl Peptidase IV (DPP4), Rat, ELISA Kit - SEA884Ra from ARP American Research Products
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Rat ADA ELISA Kit - RA0639 from NeoScientific
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Rat Ada ELISA Kit - E074676 from Biobool
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ADA ELISA Kit (Rat) (OKEH06181) - OKEH06181 from Aviva Systems Biology
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Rat ADA ELISA Kit - ERA0639 from ABclonal
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Adenosine deaminase, ELISA Kit - MBS2880930 from MyBioSource
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