| Gene Symbol |
Sema4d
|
| Entrez Gene |
20354
|
| Alt Symbol |
CD100, Semacl2, Semaj, Semcl2, coll-4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
|
| Other Description |
M-sema G|sema J|semaphorin H|semaphorin-4D|semaphorin-C-like 2|semaphorin-J
|
| Swissprots |
Q6GTM9 O09126
|
| Accessions |
EDL41105 EDL41106 EDL41107 O09126 AK088653 BAC40480 AK132688 BAE21302 AK150911 BC027681 BC049780 AAH49780 BE692125 U69535 AAC52964 XM_006516883 XP_006516946 XM_006516884 XP_006516947 XM_006516885 XP_006516948 XM_006516886 XP_006516949 XM_006516887 XP_006516950 XM_006516888 XP_006516951 XM_006516891 XP_006516954 XM_006516892 XP_006516955 NM_001281880 NP_001268809 NM_013660 NP_038688
|
| Function |
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues.
|
| Top Pathways |
Axon guidance
|