| Gene Symbol | Sema4d |
|---|---|
| Entrez Gene | 20354 |
| Alt Symbol | CD100, Semacl2, Semaj, Semcl2, coll-4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
| Other Description | M-sema G|sema J|semaphorin H|semaphorin-4D|semaphorin-C-like 2|semaphorin-J |
| Swissprots | Q6GTM9 O09126 |
| Accessions | EDL41105 EDL41106 EDL41107 O09126 AK088653 BAC40480 AK132688 BAE21302 AK150911 BC027681 BC049780 AAH49780 BE692125 U69535 AAC52964 XM_006516883 XP_006516946 XM_006516884 XP_006516947 XM_006516885 XP_006516948 XM_006516886 XP_006516949 XM_006516887 XP_006516950 XM_006516888 XP_006516951 XM_006516891 XP_006516954 XM_006516892 XP_006516955 NM_001281880 NP_001268809 NM_013660 NP_038688 |
| Function | Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. |
| Top Pathways | Axon guidance |
CD100 CRISPR/Cas9 KO Plasmid (m) - sc-422883 from Santa Cruz Biotechnology
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CD100 HDR Plasmid (m) - sc-422883-HDR from Santa Cruz Biotechnology
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CD100 Double Nickase Plasmid (m) - sc-422883-NIC from Santa Cruz Biotechnology
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CD100 Double Nickase Plasmid (m2) - sc-422883-NIC-2 from Santa Cruz Biotechnology
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CD100 CRISPR Activation Plasmid (m) - sc-422883-ACT from Santa Cruz Biotechnology
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CD100 CRISPR Activation Plasmid (m2) - sc-422883-ACT-2 from Santa Cruz Biotechnology
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CD100 Lentiviral Activation Particles (m) - sc-422883-LAC from Santa Cruz Biotechnology
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CD100 Lentiviral Activation Particles (m2) - sc-422883-LAC-2 from Santa Cruz Biotechnology
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CD100 siRNA (m) - sc-42818 from Santa Cruz Biotechnology
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CD100 shRNA Plasmid (m) - sc-42818-SH from Santa Cruz Biotechnology
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CD100 shRNA (m) Lentiviral Particles - sc-42818-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN40899 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40899 from Sigma-Aldrich
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SEMA4D siRNA (Mouse) - CRM3667 from Cohesion Biosciences
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SEMA4D - MBS8228394 from MyBioSource
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shRNA set against Mouse SEMA4D (NM_013660.3) - SHH404308 from Creative biogene
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shRNA set against Mouse Sema4d(NM_013660.3) - SHR213792 from Creative biogene
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CD100 CRISPR/Cas9 KO Plasmid (m2) - sc-422883-KO-2 from Santa Cruz Biotechnology
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CD100 HDR Plasmid (m2) - sc-422883-HDR-2 from Santa Cruz Biotechnology
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SEMA4D shRNA Plasmid (Mouse) - CHM3667 from Cohesion Biosciences
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SEMA4D miRNA 3'UTR clone - MiUTR1M-10536 from Creative biogene
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