Gene Symbol | Acpp |
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Entrez Gene | 56318 |
Alt Symbol | 5'-NT, A030005E02Rik, FRAP, Lap, PAP, Ppal |
Species | Mouse |
Gene Type | protein-coding |
Description | acid phosphatase, prostate |
Other Description | 5'-nucleotidase|TMPase|ecto-5'-nucleotidase|fluoride-resistant acid phosphatase|lysosomal acid phosphatase|prostatic acid phosphatase|thiamine monophosphatase |
Swissprots | B8JJZ5 A4QPG2 Q8CE08 Q9QXH7 Q8C682 B8JJZ6 |
Accessions | EDL21089 EDL21090 EDL21091 Q8CE08 AA589479 AF210243 AAF23171 AK020693 AK029273 BAC26366 AK076383 BAC36318 AK163330 BAE37304 AK194238 BB760697 BC139826 AAI39827 BI697921 CD770300 NM_019807 NP_062781 NM_207668 NP_997551 |
Function | A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250}. |
Subcellular Location | Isoform 1: Secreted {ECO:0000250}. |
Tissue Specificity | Isoform 1 is expressed in salivary gland, thymus and thyroid gland. Isoform 2 is widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non- peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons. {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:18940592, ECO:0000269|PubMed:20084276}. |
Top Pathways | Riboflavin metabolism |
PAcP (Y-20) - sc-23220 from Santa Cruz Biotechnology
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Anti-Prostatic Acid Phosphatase antibody - ab134457 from Abcam
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mTOR antibody - 70R-34281 from Fitzgerald
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Prostatic Acid Phosphatase antibody - orb231750 from Biorbyt
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mTOR antibody (Ser2448) - 70R-34280 from Fitzgerald
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ACPP / Prostatic acid phosphatase (Pain System Marker) antibody - AP31817PU-N from Acris Antibodies
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Anti-Prostatic Acid Phosphatase Antibody - AC11-0333 from Abcore
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Anti-ACPP antibody - STJ71924 from St John's Laboratory Ltd
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Acid Phosphatase 3, Prostatic (ACP3), Polyclonal Antibody - MBS2005636 from MyBioSource
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Rabbit Anti-Human ACPP Polyclonal Antibody - DPABH-28556 from Creative Diagnostics
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Prostatic Acid Phosphatase / ACPP Antibody, Rabbit MAb - 51018-R202-50 from Sino Biological
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Prostatic Acid Phosphatase / ACPP Antibody, Rabbit PAb, Antigen Affinity Purified - 51018-T16-50 from Sino Biological
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mTOR antibody - 70R-49762 from Fitzgerald
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Prostatic-Acid-Phosphatase-PAP-Antibody - AVS10025 from Abgent, a WuXi AppTec company
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Prostatic Acid Phosphatase / ACPP Antibody, Rabbit MAb - 51018-R205-50 from Sino Biological
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