| Gene Symbol | Acpp |
|---|---|
| Entrez Gene | 56318 |
| Alt Symbol | 5'-NT, A030005E02Rik, FRAP, Lap, PAP, Ppal |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | acid phosphatase, prostate |
| Other Description | 5'-nucleotidase|TMPase|ecto-5'-nucleotidase|fluoride-resistant acid phosphatase|lysosomal acid phosphatase|prostatic acid phosphatase|thiamine monophosphatase |
| Swissprots | B8JJZ5 A4QPG2 Q8CE08 Q9QXH7 Q8C682 B8JJZ6 |
| Accessions | EDL21089 EDL21090 EDL21091 Q8CE08 AA589479 AF210243 AAF23171 AK020693 AK029273 BAC26366 AK076383 BAC36318 AK163330 BAE37304 AK194238 BB760697 BC139826 AAI39827 BI697921 CD770300 NM_019807 NP_062781 NM_207668 NP_997551 |
| Function | A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform 1: Secreted {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is expressed in salivary gland, thymus and thyroid gland. Isoform 2 is widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non- peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons. {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:18940592, ECO:0000269|PubMed:20084276}. |
| Top Pathways | Riboflavin metabolism |
PAcP CRISPR/Cas9 KO Plasmid (m) - sc-425085 from Santa Cruz Biotechnology
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PAcP HDR Plasmid (m) - sc-425085-HDR from Santa Cruz Biotechnology
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PAcP Double Nickase Plasmid (m) - sc-425085-NIC from Santa Cruz Biotechnology
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PAcP Double Nickase Plasmid (m2) - sc-425085-NIC-2 from Santa Cruz Biotechnology
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PAcP CRISPR Activation Plasmid (m) - sc-425085-ACT from Santa Cruz Biotechnology
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PAcP CRISPR Activation Plasmid (m2) - sc-425085-ACT-2 from Santa Cruz Biotechnology
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PAcP Lentiviral Activation Particles (m) - sc-425085-LAC from Santa Cruz Biotechnology
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PAcP Lentiviral Activation Particles (m2) - sc-425085-LAC-2 from Santa Cruz Biotechnology
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PAcP siRNA (m) - sc-39120 from Santa Cruz Biotechnology
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PAcP shRNA Plasmid (m) - sc-39120-SH from Santa Cruz Biotechnology
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PAcP shRNA (m) Lentiviral Particles - sc-39120-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU025211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26179 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26179 from Sigma-Aldrich
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ACPP siRNA (Mouse) - CRM5720 from Cohesion Biosciences
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ACPP - MBS8225756 from MyBioSource
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shRNA set against Mouse ACPP (NM_019807.2) - SHH230614 from Creative biogene
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shRNA set against Mouse Acpp(NM_207668.2) - SHG031075 from Creative biogene
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shRNA set against Mouse Acpp(NM_019807.2) - SHG031111 from Creative biogene
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ACPP shRNA Plasmid (Mouse) - CHM5720 from Cohesion Biosciences
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ACPP miRNA 3'UTR clone - MiUTR1M-01128 from Creative biogene
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ACPP miRNA 3'UTR clone - MiUTR1M-01129 from Creative biogene
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