| Gene Symbol |
Acpp
|
| Entrez Gene |
56318
|
| Alt Symbol |
5'-NT, A030005E02Rik, FRAP, Lap, PAP, Ppal
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
acid phosphatase, prostate
|
| Other Description |
5'-nucleotidase|TMPase|ecto-5'-nucleotidase|fluoride-resistant acid phosphatase|lysosomal acid phosphatase|prostatic acid phosphatase|thiamine monophosphatase
|
| Swissprots |
B8JJZ5 A4QPG2 Q8CE08 Q9QXH7 Q8C682 B8JJZ6
|
| Accessions |
EDL21089 EDL21090 EDL21091 Q8CE08 AA589479 AF210243 AAF23171 AK020693 AK029273 BAC26366 AK076383 BAC36318 AK163330 BAE37304 AK194238 BB760697 BC139826 AAI39827 BI697921 CD770300 NM_019807 NP_062781 NM_207668 NP_997551
|
| Function |
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform 1: Secreted {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed in salivary gland, thymus and thyroid gland. Isoform 2 is widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non- peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons. {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:18940592, ECO:0000269|PubMed:20084276}.
|
| Top Pathways |
Riboflavin metabolism
|